Mariusz R Wieckowski
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Explore the profile of Mariusz R Wieckowski including associated specialties, affiliations and a list of published articles.
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146
Citations
7974
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Recent Articles
1.
Lebiedzinska-Arciszewska M, Pakula B, Bonora M, Missiroli S, Potes Y, Jakubek-Olszewska P, et al.
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684546
p66Shc is an adaptor protein and one of the cellular fate regulators since it modulates mitogenic signaling pathways, mitochondrial function, and reactive oxygen species (ROS) production. p66Shc is localized mostly...
2.
Lebiedzinska-Arciszewska M, Suski J, Bonora M, Pakula B, Pinton P, Duszynski J, et al.
Methods Mol Biol
. 2024 Nov;
2878():133-162.
PMID: 39546261
Mitochondria are considered one of the main sites of reactive oxygen species (ROS) production in the eukaryotic cells. For this reason, mitochondrial dysfunction associated with increased ROS production underlies various...
3.
Wydrych A, Pakula B, Jakubek-Olszewska P, Janikiewicz J, Dobosz A, Cudna A, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Oct;
1871(1):167541.
PMID: 39419454
Mutations in the following genes: PANK2, PLA2G6, C19orf12, WDR45, CP, FA2H, ATP13A2, FTL, DCAF17, and CoASY are associated with the development of different subtypes of inherited rare disease Neurodegeneration with...
4.
Prill M, Sardao V, Sobczak M, Nowis D, Szymanski J, Wieckowski M
Cancers (Basel)
. 2024 Oct;
16(19).
PMID: 39409944
This work presents a comprehensive evaluation of the role of p66Shc protein in mitochondrial physiology in MDA-MB-231 breast cancer cells. The use of human breast cancer cell line MDA-MB-231 and...
5.
van de Wal M, Doornbos C, Bibbe J, Homberg J, Van Karnebeek C, Huynen M, et al.
Biochim Biophys Acta Proteins Proteom
. 2024 Oct;
1873(1):141055.
PMID: 39395749
Paediatric Leigh syndrome (LS) is an early-onset and fatal neurodegenerative disorder lacking treatment options. LS is frequently caused by mutations in the NDUFS4 gene, encoding an accessory subunit of mitochondrial...
6.
Wydrych A, Pakula B, Janikiewicz J, Dobosz A, Jakubek-Olszewska P, Skowronska M, et al.
Biochim Biophys Acta Bioenerg
. 2024 Oct;
1866(1):149517.
PMID: 39366438
Neurodegeneration with brain iron accumulation (NBIA) is a broad, heterogeneous group of rare inherited diseases (1-3 patients/1,000,000 people) characterized by progressive symptoms associated with excessive abnormal iron deposition in the...
7.
Trentini M, DAmora U, Ronca A, Lovatti L, Calvo-Guirado J, Licastro D, et al.
Int J Nanomedicine
. 2024 Aug;
19:8695-8707.
PMID: 39205866
Introduction: In the process of bone regeneration, a prominent role is played by macrophages involved in both the initial inflammation and the regeneration/vascularization phases, due to their M2 anti-inflammatory phenotype....
8.
Jakubek P, Parchem K, Wieckowski M, Bartoszek A
Int J Mol Sci
. 2024 Jul;
25(14).
PMID: 39063068
Oxidative stress has been known about in biological sciences for several decades; however, the understanding of this concept has evolved greatly since its foundation. Over the past years, reactive oxygen...
9.
Aguilar K, Jakubek P, Zorzano A, Wieckowski M
Eur J Clin Invest
. 2024 Apr;
54(7):e14217.
PMID: 38644687
Objectives And Scope: Primary mitochondrial diseases (PMDs) are rare genetic disorders resulting from mutations in genes crucial for effective oxidative phosphorylation (OXPHOS) that can affect mitochondrial function. In this review,...
10.
Jakubek P, Kalinowski P, Karkucinska-Wieckowska A, Kaikini A, Simoes I, Potes Y, et al.
FASEB J
. 2024 Feb;
38(3):e23466.
PMID: 38318780
Despite decades of research, the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) is still not completely understood. Based on the evidence from preclinical models, one of the factors proposed...