Marioara F Ciuculescu
Overview
Explore the profile of Marioara F Ciuculescu including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
207
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0
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Recent Articles
1.
Spencer Chapman M, Cull A, Ciuculescu M, Esrick E, Mitchell E, Jung H, et al.
Nat Med
. 2023 Nov;
29(12):3175-3183.
PMID: 37973947
Gene therapy (GT) provides a potentially curative treatment option for patients with sickle cell disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials has prompted concern, with...
2.
Archer N, Gnangnon B, Mikdar M, Ciuculescu M, Petersen N, Staffa S, et al.
Am J Hematol
. 2023 Aug;
98(10):1598-1605.
PMID: 37584425
Background: Sickle cell disease (SCD) remains prevalent because heterozygous carriers (HbAS) are partially resistant to Plasmodium falciparum malaria. Sickle hemoglobin (HbS) polymerization in low and intermediate oxygen (O ) conditions...
3.
Esrick E, Lehmann L, Biffi A, Achebe M, Brendel C, Ciuculescu M, et al.
N Engl J Med
. 2020 Dec;
384(3):205-215.
PMID: 33283990
Background: Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-globins may ameliorate these manifestations...
4.
Mino A, Troeger A, Brendel C, Cantor A, Harris C, Ciuculescu M, et al.
Small GTPases
. 2016 Aug;
9(3):260-273.
PMID: 27574848
RhoH is a haematopoietic -specific, GTPase-deficient Rho GTPase that plays an essential role in T lymphocyte development and haematopoietic cell migration. RhoH is known to interact with ZAP70 in T...
5.
Ciuculescu M, Park S, Canty K, Mathieu R, Silberstein L, Williams D
Blood
. 2015 Apr;
125(20):3105-13.
PMID: 25824687
Hematopoietic stem cells (HSCs) are localized within specialized microenvironments throughout the BM. Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are important in the perivascular space. Rac is critical for MSC cell...
6.
Ciuculescu M, Brendel C, Harris C, Williams D
Methods Mol Biol
. 2014 Jul;
1185:287-309.
PMID: 25062637
Genetic modification of cells using retroviral vectors is the method of choice when the cell population is difficult to transfect and/or requires persistent transgene expression in progeny cells. There are...