Mario H Barros
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Explore the profile of Mario H Barros including associated specialties, affiliations and a list of published articles.
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45
Citations
1106
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Recent Articles
1.
Soares M, Franco L, Chagas J, Gomes F, Barros M
FEBS J
. 2025 Feb;
PMID: 39932033
Based on available platforms detailing the Saccharomyces cerevisiae mitochondrial proteome and other high-throughput studies, we identified the yeast gene DMO2 as having a profile of genetic and physical interactions that...
2.
Franco L, Barros M
IUBMB Life
. 2023 Jul;
75(12):972-982.
PMID: 37470229
The insertion of genes into mitochondria by biolistic transformation is currently only possible in the yeast Saccharomyces cerevisiae and the algae Chlamydomonas reinhardtii. The fact that S. cerevisiae mitochondria can...
3.
Chagas J, Soares M, Franco L, Barros M
J Biol Chem
. 2022 Jul;
298(8):102214.
PMID: 35779633
Mitochondrial translation is a highly regulated process, and newly synthesized mitochondrial products must first associate with several nuclear-encoded auxiliary factors to form oxidative phosphorylation complexes. The output of mitochondrial products...
4.
Paulela J, Gomes F, Camandona V, Alegria T, Netto L, Bleicher L, et al.
FEMS Yeast Res
. 2021 Nov;
21(7).
PMID: 34755843
Coenzyme Q (CoQ) is an essential molecule that consists of a highly substituted benzene ring attached to a polyprenyl tail anchored in the inner mitochondrial membrane. CoQ transfers electrons from...
5.
Santos B, Zeng R, Jorge S, Ribamar Ferreira-Junior J, Barrientos A, Barros M
Yeast
. 2021 Oct;
39(3):208-229.
PMID: 34713496
In Saccharomyces cerevisiae, mitoribosomes are composed of a 54S large subunit (mtLSU) and a 37S small subunit (mtSSU). The two subunits altogether contain 73 mitoribosome proteins (MRPs) and two ribosomal...
6.
Franco L, Bremner L, Barros M
Life (Basel)
. 2020 Nov;
10(11).
PMID: 33238568
The ease with which the unicellular yeast can be manipulated genetically and biochemically has established this organism as a good model for the study of human mitochondrial diseases. The combined...
7.
Seshadri S, Banarjee C, Barros M, Fontanesi F
Nucleic Acids Res
. 2020 May;
48(12):6759-6774.
PMID: 32449921
Mitoribosome biogenesis is an expensive metabolic process that is essential to maintain cellular respiratory capacity and requires the stoichiometric accumulation of rRNAs and proteins encoded in two distinct genomes. In...
8.
Bradley M, Yang K, Fernandez-Del-Rio L, Ngo J, Ayer A, Tsui H, et al.
J Biol Chem
. 2020 Mar;
295(18):6023-6042.
PMID: 32205446
Coenzyme Q (Q ) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast , deletion...
9.
Barros M, McStay G
Mitochondrion
. 2019 Nov;
50:94-114.
PMID: 31669617
Mitochondrial function relies on the activity of oxidative phosphorylation to synthesise ATP and generate an electrochemical gradient across the inner mitochondrial membrane. These coupled processes are mediated by five multi-subunit...
10.
Leme J, Ohara E, Santiago V, Barros M, Netto L, Pimenta D, et al.
Arch Biochem Biophys
. 2019 Apr;
666:63-72.
PMID: 30940569
In addition to autophagy, proteasomes are critical for regulating intracellular protein levels and removing misfolded proteins. The 20S proteasome (20SPT), the central catalytic unit, is sometimes flanked by regulatory units...