Mario Caruana
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    Explore the profile of Mario Caruana including associated specialties, affiliations and a list of published articles.
          
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          Snapshot
              Articles
              14
            
            
              Citations
              461
            
            
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  Recent Articles
          1.
        
    
    Lacey H, Gill R, Joshi D, Caruana M
  
  
    BMJ Case Rep
    . 2024 Jul;
          17(7).
    
    PMID: 38960421
  
  
          We present a rare case of short-segment jejunal infarction following inferior mesenteric artery embolisation for type 2 endoleak in a patient who previously underwent endovascular repair of abdominal aortic aneurysm....
      
2.
        
    
    Caruana M, Camilleri A, Farrugia M, Ghio S, Jakubickova M, Cauchi R, et al.
  
  
    Molecules
    . 2021 Apr;
          26(5).
    
    PMID: 33799979
  
  
          The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here,...
      
3.
        
    
    Farrugia M, Caruana M, Ghio S, Camilleri A, Farrugia C, Cauchi R, et al.
  
  
    Sci Rep
    . 2020 Oct;
          10(1):17733.
    
    PMID: 33082392
  
  
          Studies on the amyloidogenic N-terminal domain of the E. coli HypF protein (HypF-N) have contributed significantly to a detailed understanding of the pathogenic mechanisms in neurodegenerative diseases characterised by the...
      
4.
        
    
    Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, et al.
  
  
    Biochim Biophys Acta Biomembr
    . 2019 Sep;
          1862(2):183064.
    
    PMID: 31521630
  
  
          Misfolding and aggregate formation by the tau protein has been closely related with neurotoxicity in a large group of human neurodegenerative disorders, which includes Alzheimer's disease. Here, we investigate the...
      
5.
        
    
    Ghio S, Camilleri A, Caruana M, Ruf V, Schmidt F, Leonov A, et al.
  
  
    ACS Chem Neurosci
    . 2019 Jul;
          10(8):3815-3829.
    
    PMID: 31356747
  
  
          Aggregation of the amyloid-forming α-synuclein (αS) protein is closely associated with the etiology of Parkinson's disease (PD), the most common motor neurodegenerative disorder. Many studies have shown that soluble aggregation...
      
6.
        
    
    Martinez Hernandez A, Urbanke H, Gillman A, Lee J, Ryazanov S, Agbemenyah H, et al.
  
  
    EMBO Mol Med
    . 2017 Dec;
          10(1):32-47.
    
    PMID: 29208638
  
  
          Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal...
      
7.
        
    
    Briffa M, Ghio S, Neuner J, Gauci A, Cacciottolo R, Marchal C, et al.
  
  
    Neurosci Lett
    . 2016 Dec;
          638:12-20.
    
    PMID: 27919712
  
  
          A signature feature of age-related neurodegenerative proteinopathies is the misfolding and aggregation of proteins, typically amyloid-β (Aβ) in Alzheimer's disease (AD) and α-synuclein (α-syn) in Parkinson's disease (PD), into soluble...
      
8.
        
    Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's Disease
  
  
    
    Caruana M, Cauchi R, Vassallo N
  
  
    Front Nutr
    . 2016 Aug;
          3:31.
    
    PMID: 27570766
  
  
          Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders and hence pose remarkable socio-economical burdens to both families and state. Although AD and PD have...
      
9.
        
    
    Caruana M, Vassallo N
  
  
    Adv Exp Med Biol
    . 2015 Jun;
          863:117-37.
    
    PMID: 26092629
  
  
          Parkinson's disease (PD) is a common motor neurodegenerative disorder with multifactorial etiology that is an increasing burden on our aging society. PD is characterized by nigrostriatal degeneration which might involve...
      
10.
        
    
    Camilleri A, Zarb C, Caruana M, Ostermeier U, Ghio S, Hogen T, et al.
  
  
    Biochim Biophys Acta
    . 2013 Jul;
          1828(11):2532-43.
    
    PMID: 23817009
  
  
          Alzheimer's disease and Parkinson's disease are neurodegenerative disorders characterised by the misfolding of proteins into soluble prefibrillar aggregates. These aggregate complexes disrupt mitochondrial function, initiating a pathophysiological cascade leading to...