Marina Laplana
Overview
Explore the profile of Marina Laplana including associated specialties, affiliations and a list of published articles.
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21
Citations
379
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Recent Articles
1.
Laghouaouta H, Laplana M, Ros-Freixedes R, Fraile L, Pena R
J Anim Breed Genet
. 2024 Jul;
142(1):79-91.
PMID: 38967062
The current work aimed to identify genomic regions and candidate genes associated with resilience in pigs. In previous work, we proposed the body weight deviation from the expected growth curve...
2.
Garcia-Alberca J, de Rojas I, Sanchez-Mejias E, Garrido-Martin D, Gonzalez-Palma L, Jimenez S, et al.
J Alzheimers Dis
. 2024 Mar;
98(2):601-618.
PMID: 38427484
Background: Microglial dysfunction plays a causative role in Alzheimer's disease (AD) pathogenesis. Here we focus on a germline insertion/deletion variant mapping SIRPβ1, a surface receptor that triggers amyloid-β(Aβ) phagocytosis via...
3.
Laplana M, Royo J, Real L
Methods Mol Biol
. 2024 Jan;
2751:19-30.
PMID: 38265707
Studying host-pathogen interactions at a molecular level has always been technically challenging. Identifying the different biochemical and genetic pathways involved in the different stages of infection traditionally require complex molecular...
4.
Laplana M, Lopez-Ortega R, Fibla J
Int J Med Inform
. 2024 Jan;
183:105333.
PMID: 38184939
Background: Polygenic risk scores (PRS) are a powerful tool for predicting an individual's genetic risk for complex diseases. Methods: We have developed a web service (PRScomp) as a user-friendly tool...
5.
Chung F, Gonzalez Maldonado S, Nemc A, Bouaoun L, Cahais V, Cuenin C, et al.
Clin Epigenetics
. 2023 Jun;
15(1):102.
PMID: 37309009
Background: Epigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily accessible specimens such as blood and urine. These...
6.
Fibla J, Maceda I, Laplana M, Guerrero M, Alvarez M, Burgueno J, et al.
Front Genet
. 2023 Jan;
13:1100440.
PMID: 36704333
The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events. However, less is known about factors affecting mating patterns at a...
7.
Faltus C, Lahnsteiner A, Barrdahl M, Assenov Y, Husing A, Bogatyrova O, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142605
Changes in DNA methylation identified by epigenome-wide association studies (EWAS) have been recently linked to increased lung cancer risk. However, the cellular effects of these differentially methylated positions (DMPs) are...
8.
Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers
Laplana M, Bieg M, Faltus C, Melnik S, Bogatyrova O, Gu Z, et al.
Epigenetics
. 2021 Feb;
17(2):117-132.
PMID: 33595421
Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are...
9.
Laplana M, Yuguero O, Fibla J
PLoS One
. 2020 Dec;
15(12):e0243598.
PMID: 33315903
Background: The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods: We performed...
10.
Laplana M, Bravo M, Fernandez-Fuertes M, Ruiz-Garcia C, Alarcon-Martin E, Colmenero J, et al.
J Infect Dis
. 2020 Jun;
222(12):2007-2011.
PMID: 32516401
Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its...