Mariko Izumo
Overview
Explore the profile of Mariko Izumo including associated specialties, affiliations and a list of published articles.
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13
Citations
664
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Recent Articles
1.
Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks
Acosta-Rodriguez V, Rijo-Ferreira F, van Rosmalen L, Izumo M, Park N, Joseph C, et al.
Cell Rep
. 2024 Jul;
43(8):114523.
PMID: 39046875
Extended food consumption during the rest period perturbs the phase relationship between circadian clocks in the periphery and the brain, leading to adverse health effects. Beyond the liver, how metabolic...
2.
Kanan M, Sheehan P, Haines J, Gomez P, Dhuler A, Nadarajah C, et al.
JCI Insight
. 2023 Nov;
9(2).
PMID: 38032732
Circadian rhythm dysfunction is a hallmark of Parkinson disease (PD), and diminished expression of the core clock gene Bmal1 has been described in patients with PD. BMAL1 is required for...
3.
Frazier K, Manzoor S, Carroll K, DeLeon O, Miyoshi S, Miyoshi J, et al.
J Clin Invest
. 2023 Sep;
133(18).
PMID: 37712426
Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mechanisms remain...
4.
Acosta-Rodriguez V, Rijo-Ferreira F, Izumo M, Xu P, Wight-Carter M, Green C, et al.
Science
. 2022 May;
376(6598):1192-1202.
PMID: 35511946
Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising...
5.
Shan Y, Abel J, Li Y, Izumo M, Cox K, Jeong B, et al.
Neuron
. 2020 Aug;
108(1):164-179.e7.
PMID: 32768389
The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavior and physiology. Although the SCN is small, it is composed of many cell types, making it difficult to...
6.
Lananna B, Nadarajah C, Izumo M, Cedeno M, Xiong D, Dimitry J, et al.
Cell Rep
. 2018 Oct;
25(1):1-9.e5.
PMID: 30282019
Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults and...
7.
Hasegawa M, Majima K, Itokazu T, Maki T, Albrecht U, Castner N, et al.
Cell Rep
. 2017 Mar;
18(11):2676-2686.
PMID: 28297671
Prepared movements are more efficient than those that are not prepared for. Although changes in cortical activity have been observed prior to a forthcoming action, the circuits involved in motor...
8.
Lee I, Chang A, Manandhar M, Shan Y, Fan J, Izumo M, et al.
Neuron
. 2015 Mar;
85(5):1086-102.
PMID: 25741729
Circadian behavior in mammals is orchestrated by neurons within the suprachiasmatic nucleus (SCN), yet the neuronal population necessary for the generation of timekeeping remains unknown. We show that a subset...
9.
Izumo M, Pejchal M, Schook A, Lange R, Walisser J, Sato T, et al.
Elife
. 2014 Dec;
3.
PMID: 25525750
In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout...
10.
Shimomura K, Lowrey P, Vitaterna M, Buhr E, Kumar V, Hanna P, et al.
Proc Natl Acad Sci U S A
. 2010 Apr;
107(18):8399-403.
PMID: 20404168
Most laboratory mouse strains including C57BL/6J do not produce detectable levels of pineal melatonin owing to deficits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT), two...