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Marie Simpson

Explore the profile of Marie Simpson including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Harrison A, Gardner I, Hay T, Dickins M, Beaumont K, Phipps A, et al.
Xenobiotica . 2011 Oct; 42(1):57-74. PMID: 21992032
PF-184298 ((S)-2,3-dichloro-N-isobutyl-N-pyrrolidin-3-ylbenzamide) and PF-4776548 ((3-(4-fluoro-2-methoxy-benzyl)-7-hydroxy-8,9-dihydro-3H,7H-pyrrolo[2,3-c][1,7]naphthyridin-6-one)) are novel compounds which were selected to progress to human studies. Discordant human pharmacokinetic predictions arose from pre-clinical in vivo studies in rat and dog,...
2.
Wagner C, Simpson M, Zeitlinger M, Bauer M, Karch R, Abrahim A, et al.
Clin Pharmacokinet . 2010 Dec; 50(2):111-20. PMID: 21142292
Background And Objective: In microdose studies, the pharmacokinetic profile of a drug in blood after administration of a dose up to 100 μg is measured with sensitive analytical techniques, such...