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Marie-France Carlier

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Articles 87
Citations 4319
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Mahuzier A, Shihavuddin A, Fournier C, Lansade P, Faucourt M, Menezes N, et al.
Nat Commun . 2018 Jun; 9(1):2279. PMID: 29891944
Multiciliated ependymal cells line all brain cavities. The beating of their motile cilia contributes to the flow of cerebrospinal fluid, which is required for brain homoeostasis and functions. Motile cilia,...
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Shekhar S, Carlier M
Curr Biol . 2017 Jun; 27(13):1990-1998.e5. PMID: 28625780
A living cell's ability to assemble actin filaments in intracellular motile processes is directly dependent on the availability of polymerizable actin monomers, which feed polarized filament growth [1, 2]. Continued...
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Dimchev G, Steffen A, Kage F, Dimchev V, Pernier J, Carlier M, et al.
Mol Biol Cell . 2017 Mar; 28(10):1311-1325. PMID: 28331069
Cell migration and cell-cell communication involve the protrusion of actin-rich cell surface projections such as lamellipodia and filopodia. Lamellipodia are networks of actin filaments generated and turned over by filament...
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Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, et al.
Nat Commun . 2017 Mar; 8:14832. PMID: 28327544
Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are...
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Carlier M, Shekhar S
Nat Rev Mol Cell Biol . 2017 Mar; 18(6):389-401. PMID: 28248322
Various cellular processes (including cell motility) are driven by the regulated, polarized assembly of actin filaments into distinct force-producing arrays of defined size and architecture. Branched, linear, contractile and cytosolic...
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Shekhar S, Pernier J, Carlier M
J Cell Sci . 2016 Mar; 129(6):1085-91. PMID: 26940918
Cells respond to external stimuli by rapidly remodeling their actin cytoskeleton. At the heart of this function lies the intricately controlled regulation of individual filaments. The barbed end of an...
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Pernier J, Shekhar S, Jegou A, Guichard B, Carlier M
Dev Cell . 2016 Jan; 36(2):201-14. PMID: 26812019
Cell motility and actin homeostasis depend on the control of polarized growth of actin filaments. Profilin, an abundant regulator of actin dynamics, supports filament assembly at barbed ends by binding...
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Shekhar S, Carlier M
Mol Biol Cell . 2015 Dec; 27(1):1-6. PMID: 26715420
Polarized assembly of actin filaments forms the basis of actin-based motility and is regulated both spatially and temporally. Cells use a variety of mechanisms by which intrinsically slower processes are...
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Montaville P, Kuhn S, Compper C, Carlier M
J Biol Chem . 2015 Dec; 291(7):3302-18. PMID: 26668326
Formin 2 (Fmn2), a member of the FMN family of formins, plays an important role in early development. This formin cooperates with profilin and Spire, a WASP homology domain 2...