Marie-Eve Lalonde
Overview
Explore the profile of Marie-Eve Lalonde including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1166
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Recent Articles
1.
Lalonde M, Sasseville M, Gelinas A, Milanese J, Beland K, Drouin S, et al.
Haematologica
. 2022 Sep;
108(2):382-393.
PMID: 36134452
Acute lymphoblastic leukemia (ALL) is the most frequent cancer diagnosed in children. Despite the great progress achieved over the last 40 years, with cure rates now exceeding 85%, refractory or...
2.
Sudarshan D, Avvakumov N, Lalonde M, Alerasool N, Joly-Beauparlant C, Jacquet K, et al.
Genes Dev
. 2022 Jun;
36(11-12):664-683.
PMID: 35710139
Chromosomal translocations frequently promote carcinogenesis by producing gain-of-function fusion proteins. Recent studies have identified highly recurrent chromosomal translocations in patients with endometrial stromal sarcomas (ESSs) and ossifying fibromyxoid tumors (OFMTs),...
3.
Lalonde M, Koyuturk I, Brochu D, Jabbour J, Gilbert M, Durocher Y
J Biotechnol
. 2019 Nov;
307:87-97.
PMID: 31697975
Alpha-1-antitrypsin (A1AT) is an abundant serum inhibitor of serine proteases. A1AT deficiency is a common genetic disorder which is currently treated with augmentation therapies. These treatments involve weekly injections of...
4.
Lalonde M, Durocher Y
J Biotechnol
. 2017 May;
251:128-140.
PMID: 28465209
Over the last years, the biopharmaceutical industry has significantly turned its biologics production towards mammalian cell expression systems. The presence of glycosylation machineries within these systems, and the fact that...
5.
Carbonneau M, M Gagne L, Lalonde M, Germain M, Motorina A, Guiot M, et al.
Nat Commun
. 2016 Sep;
7:12700.
PMID: 27624942
The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis....
6.
Klein B, Muthurajan U, Lalonde M, Gibson M, Andrews F, Hepler M, et al.
Nucleic Acids Res
. 2015 Dec;
44(1):472-84.
PMID: 26626149
BRPF1 (bromodomain PHD finger 1) is a core subunit of the MOZ histone acetyltransferase (HAT) complex, critical for normal developmental programs and implicated in acute leukemias. BRPF1 contains a unique...
7.
Feng Y, Vlassis A, Roques C, Lalonde M, Gonzalez-Aguilera C, Lambert J, et al.
EMBO J
. 2015 Dec;
35(2):176-92.
PMID: 26620551
During DNA replication, thousands of replication origins are activated across the genome. Chromatin architecture contributes to origin specification and usage, yet it remains unclear which chromatin features impact on DNA...
8.
Lalonde M, Cheng X, Cote J
Genes Dev
. 2014 May;
28(10):1029-41.
PMID: 24831698
Histone modifiers like acetyltransferases, methyltransferases, and demethylases are critical regulators of most DNA-based nuclear processes, de facto controlling cell cycle progression and cell fate. These enzymes perform very precise post-translational...
9.
Klein B, Lalonde M, Cote J, Yang X, Kutateladze T
Epigenetics
. 2013 Oct;
9(2):186-93.
PMID: 24169304
The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the...
10.
Lalonde M, Avvakumov N, Glass K, Joncas F, Saksouk N, Holliday M, et al.
Genes Dev
. 2013 Sep;
27(18):2009-24.
PMID: 24065767
Histone acetyltransferases (HATs) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we characterize native HAT complexes assembled by the BRPF family of scaffold...