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Marie-Christine Ailhaud

Explore the profile of Marie-Christine Ailhaud including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 70
Followers 0
Related Specialty
Pharmacology
Top 10 Co-Authors
Didier Cussac
Isabelle Rauly-Lestienne
Peter Heusler
Amelie Tourette
Adrian Newman-Tancredi
Stephanie Tardif
Elisa Boutet-Robinet
Fabrice Lestienne
Nathalie Danty
Emilie Lauressergues
Published In
Naunyn Schmiedebergs Arch Pharmacol
Eur J Pharmacol
Pharmacol Res Perspect
Cell Signal
Affiliations
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Recent Articles
1.
Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model
Lauressergues E, Heusler P, Lestienne F, Troulier D, Rauly-Lestienne I, Tourette A, et al.
Pharmacol Res Perspect . 2016 Apr; 4(2):e00214. PMID: 27069629
The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The recently approved orally active drugs vismodegib (GDC-0449) and sonidegib (LDE-225)...
2.
Competitive interaction of 5-HT(1A) receptors with G-protein subtypes in CHO cells demonstrated by RNA interference
Rauly-Lestienne I, Lestienne F, Ailhaud M, Binesse J, Newman-Tancredi A, Cussac D
Cell Signal . 2010 Aug; 23(1):58-64. PMID: 20727408
Following agonist action, G-protein-coupled receptors may exhibit differential coupling to G-proteins or second messenger pathways, supporting the notion of agonist-directed trafficking. To explore these mechanisms, we have designed and transfected...
3.
Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human alpha2-adrenoceptors: (+)8-OH-DPAT, but not (-)8-OH-DPAT is an alpha2B subtype preferential agonist
Heusler P, Rauly-Lestienne I, Tourette A, Tardif S, Ailhaud M, Croville G, et al.
Eur J Pharmacol . 2010 May; 640(1-3):8-14. PMID: 20450907
8-OH-DPAT [8-hydroxy-2-(di-n-propylamino)tetralin] is the prototypical agonist at serotonin 5-HT1A receptors; however, activity at other targets contributes to the functional effects of the compound as well. We examined the properties of...
4.
Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells
Cussac D, Boutet-Robinet E, Ailhaud M, Newman-Tancredi A, Martel J, Danty N, et al.
Eur J Pharmacol . 2008 Aug; 594(1-3):32-8. PMID: 18703043
Several examples of agonist-directed trafficking of receptor signalling at 5-HT2A and 5-HT2C receptors have been reported that involve independent downstream transduction pathways. We now report the functional selectivity of a...
5.
Activation of G proteins and extracellular signal-regulated kinase 1/2 phosphorylation via human dopamine D4.4 receptors: differential pathway-dependent potencies of receptor agonists
Heusler P, Bruins Slot L, Rauly-Lestienne I, Palmier C, Tardif S, Tourette A, et al.
Naunyn Schmiedebergs Arch Pharmacol . 2008 Aug; 379(1):87-99. PMID: 18682919
Agonist activity at recombinant human dopamine D4.4 receptors was compared in stably transfected CHO cells using two functional readouts: G protein activation by [35S]GTPgammaS binding and phosphorylation of extracellular signal-regulated...
6.
Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties
Rauly-Lestienne I, Boutet-Robinet E, Ailhaud M, Newman-Tancredi A, Cussac D
Naunyn Schmiedebergs Arch Pharmacol . 2007 Sep; 376(1-2):93-105. PMID: 17786406
5-HT(7) receptors are present in thalamus and limbic structures, and a possible role of these receptors in the pathology of schizophrenia has been evoked. In this study, we examined binding...