Maribel Munoz-Martin
Overview
Explore the profile of Maribel Munoz-Martin including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
1126
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Recent Articles
1.
Lynch C, Bernad R, Martinez-Val A, Shahbazi M, Nobrega-Pereira S, Calvo I, et al.
Nat Cell Biol
. 2020 Sep;
22(10):1223-1238.
PMID: 32989249
Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli,...
2.
Munoz-Espin D, Rovira M, Galiana I, Gimenez C, Lozano-Torres B, Paez-Ribes M, et al.
EMBO Mol Med
. 2018 Jul;
10(9).
PMID: 30012580
Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β-galactosidase activity of...
3.
Mosteiro L, Pantoja C, Alcazar N, Marion R, Chondronasiou D, Rovira M, et al.
Science
. 2016 Nov;
354(6315).
PMID: 27884981
Reprogramming of differentiated cells into pluripotent cells can occur in vivo, but the mechanisms involved remain to be elucidated. Senescence is a cellular response to damage, characterized by abundant production...
4.
Lopez-Guadamillas E, Munoz-Martin M, Martinez S, Pastor J, Fernandez-Marcos P, Serrano M
Aging (Albany NY)
. 2016 Nov;
8(11):2747-2753.
PMID: 27816049
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best known health beneficial effects of reduced PI3K are related to metabolism and...
5.
Lopez-Guadamillas E, Fernandez-Marcos P, Pantoja C, Munoz-Martin M, Martinez D, Gomez-Lopez G, et al.
Sci Rep
. 2016 Oct;
6:34542.
PMID: 27721423
Fasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of...
6.
Ortega-Molina A, Lopez-Guadamillas E, Mattison J, Mitchell S, Munoz-Martin M, Iglesias G, et al.
Cell Metab
. 2015 Mar;
21(4):558-70.
PMID: 25817535
Genetic inhibition of PI3K signaling increases energy expenditure, protects from obesity and metabolic syndrome, and extends longevity. Here, we show that two pharmacological inhibitors of PI3K, CNIO-PI3Ki and GDC-0941, decrease...
7.
Maraver A, Fernandez-Marcos P, Cash T, Mendez-Pertuz M, Duenas M, Maietta P, et al.
J Clin Invest
. 2015 Jan;
125(2):824-30.
PMID: 25574842
NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in...
8.
Maraver A, Fernandez-Marcos P, Herranz D, Munoz-Martin M, Gomez-Lopez G, Canamero M, et al.
Cancer Cell
. 2012 Aug;
22(2):222-34.
PMID: 22897852
Here, we have investigated the role of the Notch pathway in the generation and maintenance of Kras(G12V)-driven non-small cell lung carcinomas (NSCLCs). We demonstrate by genetic means that γ-secretase and...
9.
Ortega-Molina A, Efeyan A, Lopez-Guadamillas E, Munoz-Martin M, Gomez-Lopez G, Canamero M, et al.
Cell Metab
. 2012 Mar;
15(3):382-94.
PMID: 22405073
Aging in worms and flies is regulated by the PI3K/Akt/Foxo pathway. Here we extend this paradigm to mammals. Pten(tg) mice carrying additional genomic copies of Pten are protected from cancer...
10.
Herranz D, Iglesias G, Munoz-Martin M, Serrano M
Cell Cycle
. 2011 May;
10(13):2215-7.
PMID: 21606675
Dietary restriction (DR) has multiple beneficial effects, the two most prominently studied being an increased longevity and an increased cancer protection. Mammalian Sirt1 is a protein deacetylase that has been...