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Mariangeles Kovacs

Explore the profile of Mariangeles Kovacs including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 189
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Recent Articles
1.
Kovacs M, Dominguez-Belloso A, Ali-Moussa S, Deczkowska A
Nat Rev Immunol . 2025 Jan; PMID: 39890999
The peripheral immune system communicates with the brain through complex anatomical routes involving the skull, the brain borders, circumventricular organs and peripheral nerves. These immune-brain communication pathways were classically considered...
2.
Alamon C, Davila B, Garcia M, Nievas S, Dagrosa M, Thorp S, et al.
Mol Pharm . 2023 Apr; 20(5):2702-2713. PMID: 37013916
Glioblastoma (GBM), as the most central nervous system (CNS) intractable disease, has spoiled millions of lives due to its high mortality. Even though several efforts have been made, the existing...
3.
Kovacs M, Alamon C, Maciel C, Varela V, Ibarburu S, Tarrago L, et al.
Acta Neuropathol Commun . 2021 Aug; 9(1):136. PMID: 34389060
Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells trafficking from the blood also infiltrate...
4.
Alamon C, Davila B, Garcia M, Sanchez C, Kovacs M, Trias E, et al.
Cancers (Basel) . 2020 Nov; 12(11). PMID: 33218150
Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being-especially for glioblastomas-extremely poor. There are no effective treatments yet. However, tyrosine kinase receptor...
5.
Ibarburu S, Kovacs M, Varela V, Rodriguez-Duarte J, Ingold M, Invernizzi P, et al.
Neurotherapeutics . 2020 Oct; 18(1):309-325. PMID: 33118131
Motor neuron degeneration and neuroinflammation are the most striking pathological features of amyotrophic lateral sclerosis (ALS). ALS currently has no cure and approved drugs have only a modest clinically therapeutic...
6.
Couto M, Alamon C, Garcia M, Kovacs M, Trias E, Nievas S, et al.
Cells . 2020 Jun; 9(6). PMID: 32517054
One of the driving forces of carcinogenesis in humans is the aberrant activation of receptors; consequently, one of the most promising mechanisms for cancer treatment is receptor inhibition by chemotherapy....
7.
Trias E, Kovacs M, King P, Si Y, Kwon Y, Varela V, et al.
Glia . 2019 Dec; 68(6):1165-1181. PMID: 31859421
Distal axonopathy is a recognized pathological feature of amyotrophic lateral sclerosis (ALS). In the peripheral nerves of ALS patients, motor axon loss elicits a Wallerian-like degeneration characterized by denervated Schwann...
8.
Kovacs M, Trias E, Varela V, Ibarburu S, Beckman J, Moura I, et al.
Int J Mol Sci . 2019 Aug; 20(16). PMID: 31395804
Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons accompanied by proliferation of reactive microglia in affected regions. However, it is unknown whether the hematopoietic...
9.
Trias E, Beilby P, Kovacs M, Ibarburu S, Varela V, Barreto-Nunez R, et al.
Front Aging Neurosci . 2019 Mar; 11:42. PMID: 30873018
Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation...
10.
Trias E, King P, Si Y, Kwon Y, Varela V, Ibarburu S, et al.
JCI Insight . 2018 Oct; 3(19). PMID: 30282815
Neuroinflammation is a recognized pathogenic mechanism underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the inflammatory mechanisms influencing peripheral motor axon degeneration remain largely unknown. A recent report...