Maria Rosaria Domenici
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Explore the profile of Maria Rosaria Domenici including associated specialties, affiliations and a list of published articles.
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32
Citations
487
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Recent Articles
1.
Mollinari C, Cardinale A, Lupacchini L, Martire A, Chiodi V, Martinelli A, et al.
EMBO Rep
. 2024 Jul;
25(8):3707-3737.
PMID: 39085642
The key DNA repair enzyme DNA-PKcs has several and important cellular functions. Loss of DNA-PKcs activity in mice has revealed essential roles in immune and nervous systems. In humans, DNA-PKcs...
2.
Chiodi V, Rappa F, Lo Re O, Chaldakov G, Lelouvier B, Micale V, et al.
Sci Rep
. 2023 Nov;
13(1):19123.
PMID: 37926763
Obesity has a major socio-economic health impact. There are profound sex differences in adipose tissue deposition and obesity-related conditions. The underlying mechanisms driving sexual dimorphism in obesity and its associated...
3.
Mallozzi C, Pepponi R, Gaddini L, Casella I, Chiodi V, Popoli P, et al.
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759748
(1) Background: Recently, we found that adenosine A receptor (AR) stimulation results in an increase in STEP phosphatase activity. In order to delve into the mechanism through which AR stimulation...
4.
Chiodi V, Domenici M, Biagini T, De Simone R, Tartaglione A, Di Rosa M, et al.
FASEB J
. 2021 Jul;
35(8):e21793.
PMID: 34320234
Gene expression and epigenetic processes in several brain regions regulate physiological processes such as cognitive functions and social behavior. MacroH2A1.1 is a ubiquitous variant of histone H2A that regulates cell...
5.
Domenici M, Mallozzi C, Pepponi R, Casella I, Chiodi V, Ferrante A, et al.
Front Pharmacol
. 2021 May;
12:647742.
PMID: 33953681
The STriatal-Enriched protein tyrosine phosphatase STEP is a brain-specific tyrosine phosphatase that plays a pivotal role in the mechanisms of learning and memory, and it has been demonstrated to be...
6.
Mallozzi C, Pepponi R, Visentin S, Chiodi V, Lombroso P, Bader M, et al.
J Neurochem
. 2019 Sep;
152(3):284-298.
PMID: 31520531
We recently demonstrated that a tonic activation of adenosine A receptors (A Rs) is required for cocaine-induced synaptic depression and increase in the activity of STriatal-Enriched protein tyrosine Phosphatase (STEP)....
7.
Domenici M, Ferrante A, Martire A, Chiodi V, Pepponi R, Tebano M, et al.
Pharmacol Res
. 2019 Jul;
147:104338.
PMID: 31276772
Adenosine A receptor (AR) is a G-protein coupled receptor that regulates several important functions in the central nervous system. Large amount of preclinical data suggests that the AR could represent...
8.
Mallozzi C, Spalloni A, Longone P, Domenici M
Neural Plast
. 2018 Aug;
2018:2430193.
PMID: 30154836
Degeneration of cortical and spinal motor neurons is the typical feature of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease for which a pathogenetic role for the Cu/Zn superoxide dismutase...
9.
Blum D, Chern Y, Domenici M, Buee L, Lin C, Rea W, et al.
J Caffeine Adenosine Res
. 2018 Jul;
8(2):43-58.
PMID: 30023989
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the IT15 gene that encodes for the huntingtin protein. Mutated hungtingtin, although widely expressed in the brain,...
10.
Domenici M, Chiodi V, Averna M, Armida M, Pezzola A, Pepponi R, et al.
Purinergic Signal
. 2018 May;
14(3):235-243.
PMID: 29770921
The A adenosine receptor (AR) is widely distributed on different cellular types in the brain, where it exerts a broad spectrum of pathophysiological functions, and for which a role in...