Insight into the Role of the STriatal-Enriched Protein Tyrosine Phosphatase (STEP) in A Receptor-Mediated Effects in the Central Nervous System

Overview

Journal Front Pharmacol

Date 2021 May 6

PMID 33953681

Citations 4

Authors

Maria Rosaria Domenici

Cinzia Mallozzi

Rita Pepponi

Ida Casella

Valentina Chiodi

Antonella Ferrante

Patrizia Popoli

Affiliations

Soon will be listed here.

Abstract

The STriatal-Enriched protein tyrosine phosphatase STEP is a brain-specific tyrosine phosphatase that plays a pivotal role in the mechanisms of learning and memory, and it has been demonstrated to be involved in several neuropsychiatric diseases. Recently, we found a functional interaction between STEP and adenosine A receptor (AR), a subtype of the adenosine receptor family widely expressed in the central nervous system, where it regulates motor behavior and cognition, and plays a role in cell survival and neurodegeneration. Specifically, we demonstrated the involvement of STEP in AR-mediated cocaine effects in the striatum and, more recently, we found that in the rat striatum and hippocampus, as well as in a neuroblastoma cell line, the overexpression of the AR, or its stimulation, results in an increase in STEP activity. In the present article we will discuss the functional implication of this interaction, trying to examine the possible mechanisms involved in this relation between STEP and ARs.

Citing Articles

Functional Interaction between Adenosine A and mGlu Receptors Mediates STEP Phosphatase Activation and Promotes STEP/mGluR Binding in Mouse Hippocampus and Neuroblastoma Cell Line.

Mallozzi C, Pepponi R, Gaddini L, Casella I, Chiodi V, Popoli P Biomolecules. 2023; 13(9).

PMID: 37759748 PMC: 10527457. DOI: 10.3390/biom13091350.

Molecular Integration in Adenosine Heteroreceptor Complexes Through Allosteric and De-Phosphorylation (STEP) Mechanisms and its Role in Brain Disease.

Borroto-Escuela D, Ferraro L, Fuxe K Front Pharmacol. 2022; 12:781381.

PMID: 35069202 PMC: 8769210. DOI: 10.3389/fphar.2021.781381.

The active kinome: The modern view of how active protein kinase networks fit in biological research.

Alganem K, Hamoud A, Creeden J, Henkel N, Imami A, Joyce A Curr Opin Pharmacol. 2021; 62:117-129.

PMID: 34968947 PMC: 9438800. DOI: 10.1016/j.coph.2021.11.007.

The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons.

Borroto-Escuela D, Ferraro L, Beggiato S, Narvaez M, Fores-Pons R, Alvarez-Contino J Pharmacol Rep. 2021; 73(4):1096-1108.

PMID: 34426901 PMC: 8413191. DOI: 10.1007/s43440-021-00314-3.

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