Maria Pena-Chilet
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Explore the profile of Maria Pena-Chilet including associated specialties, affiliations and a list of published articles.
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55
Citations
766
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Recent Articles
1.
Maillo A, Huergo E, Apellaniz-Ruiz M, Urrutia-Lafuente E, Miranda M, Salgado J, et al.
Genes (Basel)
. 2024 May;
15(5).
PMID: 38790214
Large-scale genomic studies have significantly increased our knowledge of genetic variability across populations. Regional genetic profiling is essential for distinguishing common benign variants from disease-causing ones. To this end, we...
2.
Moura D, Mondaza-Hernandez J, Sanchez-Bustos P, Pena-Chilet M, Cordero-Varela J, Lopez-Alvarez M, et al.
Cell Mol Life Sci
. 2024 May;
81(1):219.
PMID: 38758230
HMGA1 is a structural epigenetic chromatin factor that has been associated with tumor progression and drug resistance. Here, we reported the prognostic/predictive value of HMGA1 for trabectedin in advanced soft-tissue...
3.
Esteban-Medina M, de la Oliva Roque V, Herraiz-Gil S, Pena-Chilet M, Dopazo J, Loucera C
Comput Struct Biotechnol J
. 2024 Mar;
23:1129-1143.
PMID: 38510973
We introduce drexml, a command line tool and Python package for rational data-driven drug repurposing. The package employs machine learning and mechanistic signal transduction modeling to identify drug targets capable...
4.
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie M, et al.
Front Immunol
. 2024 Feb;
14:1282859.
PMID: 38414974
Introduction: The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop...
5.
Esteban-Medina M, Loucera C, Rian K, Velasco S, Olivares-Gonzalez L, Rodrigo R, et al.
J Transl Med
. 2024 Feb;
22(1):139.
PMID: 38321543
Background: Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In the pursuit of unraveling the intricate dynamics underlying this complex disease, mechanistic...
6.
Paya-Milans M, Pena-Chilet M, Loucera C, Esteban-Medina M, Dopazo J
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834179
Soft tissue sarcoma is an umbrella term for a group of rare cancers that are difficult to treat. In addition to surgery, neoadjuvant chemotherapy has shown the potential to downstage...
7.
Loucera C, Carmona R, Esteban-Medina M, Bostelmann G, Munoyerro-Muniz D, Villegas R, et al.
Virol J
. 2023 Oct;
20(1):226.
PMID: 37803348
Purpose: Despite the extensive vaccination campaigns in many countries, COVID-19 is still a major worldwide health problem because of its associated morbidity and mortality. Therefore, finding efficient treatments as fast...
8.
Gawron P, Hoksza D, Pinero J, Pena-Chilet M, Esteban-Medina M, Fernandez-Rueda J, et al.
Front Bioinform
. 2023 Jul;
3:1101505.
PMID: 37502697
Investigation of molecular mechanisms of human disorders, especially rare diseases, require exploration of various knowledge repositories for building precise hypotheses and complex data interpretation. Recently, increasingly more resources offer diagrammatic...
9.
Corrales P, Martin-Taboada M, Vivas-Garcia Y, Torres L, Ramirez-Jimenez L, Lopez Y, et al.
Aging Cell
. 2023 Jul;
22(11):e13919.
PMID: 37403257
Caloric restriction is a non-pharmacological intervention known to ameliorate the metabolic defects associated with aging, including insulin resistance. The levels of miRNA expression may represent a predictive tool for aging-related...
10.
Nunez-Torres R, Pita G, Pena-Chilet M, Lopez-Lopez D, Zamora J, Roldan G, et al.
Pharmaceutics
. 2023 Apr;
15(4).
PMID: 37111771
The implementation of pharmacogenetics (PGx) is a main milestones of precision medicine nowadays in order to achieve safer and more effective therapies. Nevertheless, the implementation of PGx diagnostics is extremely...