Maria Lourdes Linares
Overview
Explore the profile of Maria Lourdes Linares including associated specialties, affiliations and a list of published articles.
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15
Citations
118
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Recent Articles
1.
Matico R, Grauwen K, Chauhan D, Yu X, Abdiaj I, Adhikary S, et al.
EMBO Mol Med
. 2024 Dec;
17(1):54-84.
PMID: 39653810
The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various...
2.
Alonso De Diego S, Linares M, Garcia Molina A, de Lucas A, Del Cerro A, Alonso J, et al.
J Med Chem
. 2024 Aug;
67(17):15569-15585.
PMID: 39208150
Allosteric modulators of the metabotropic group II receptors, mGluR and mGluR, have been widely explored due to their ability to modulate cognitive and neurological functions in mood disorders, although none...
3.
Odena C, Santiago T, Linares M, Castellanos-Blanco N, McGuire R, Chaves-Arquero B, et al.
J Am Chem Soc
. 2024 Jul;
146(31):21264-21270.
PMID: 39052124
Herein, we describe nickel oxidative addition complexes (Ni-OACs) of drug-like molecules as a platform to rapidly generate lead candidates with enhanced C() fraction. The potential of Ni-OACs to access new...
4.
Pijper B, Martin R, Huertas-Alonso A, Linares M, Lopez E, Llaveria J, et al.
Org Lett
. 2023 May;
26(14):2724-2728.
PMID: 37219892
Herein, we present a novel C(sp)-C(sp) bond-forming protocol via the reductive coupling of abundant tertiary amides with organozinc reagents prepared from their corresponding alkyl halides. Using a multistep fully automated...
5.
Abdiaj I, Canellas S, Dieguez A, Linares M, Pijper B, Fontana A, et al.
J Med Chem
. 2022 Dec;
66(1):716-732.
PMID: 36520521
Herein, we report an end-to-end process including synthesis, work-up, purification, and post-purification with minimal human intervention using Negishi coupling as a key transformation to increase Fsp in bioactive molecules. The...
6.
de Lucas A, Vega J, Garcia Molina A, Linares M, Tresadern G, Lavreysen H, et al.
ACS Omega
. 2021 Sep;
6(35):22997-23006.
PMID: 34514269
Glutamate hyperfunction is implicated in multiple neurological and psychiatric diseases. Activation of the mGlu2 receptor results in reduced glutamate release and decreased excitability representing a promising novel therapeutic agent for...
7.
Lopez E, Linares M, Alcazar J
Future Med Chem
. 2020 Aug;
12(17):1547-1563.
PMID: 32819155
This perspective scrutinizes flow chemistry as a useful tool for medicinal chemists to expand the current chemical capabilities in drug discovery. This technology has demonstrated his value not only for...
8.
de Lucas A, Vega J, Matesanz E, Linares M, Garcia Molina A, Tresadern G, et al.
ACS Med Chem Lett
. 2020 Mar;
11(3):303-308.
PMID: 32184961
Starting from two weak mGlu receptor positive allosteric modulator (PAM) HTS hits ( and ), a molecular hybridization strategy resulted in the identification of a novel spiro-oxindole piperidine series with...
9.
Cid J, Tresadern G, Vega J, de Lucas A, Del Cerro A, Matesanz E, et al.
J Med Chem
. 2016 Sep;
59(18):8495-507.
PMID: 27579727
Positive allosteric modulators of the metabotropic glutamate 2 receptor have generated great interest in the past decade. There is mounting evidence of their potential as therapeutic agents in the treatment...
10.
Cid J, Tresadern G, Duvey G, Lutjens R, Finn T, Rocher J, et al.
J Med Chem
. 2014 Jul;
57(15):6495-512.
PMID: 25032784
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity starting from the HTS hit 5. In this article, we describe a different exploration from 5 that led...