Maria L Valencik
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Explore the profile of Maria L Valencik including associated specialties, affiliations and a list of published articles.
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16
Citations
547
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Recent Articles
1.
Ayon R, Hawn M, Aoun J, Wiwchar M, Forrest A, Cunningham F, et al.
Am J Physiol Cell Physiol
. 2019 Aug;
317(6):C1093-C1106.
PMID: 31461344
This study explored the mechanism by which Ca-activated Cl channels (CaCCs) encoded by the gene are regulated by calmodulin-dependent protein kinase II (CaMKII) and protein phosphatases 1 (PP1) and 2A...
2.
Ba M, Surina J, Singer C, Valencik M
BMC Pharmacol Toxicol
. 2017 Jun;
18(1):47.
PMID: 28623958
Background: The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the...
3.
Leblanc N, Forrest A, Ayon R, Wiwchar M, Angermann J, Pritchard H, et al.
Pulm Circ
. 2015 Jun;
5(2):244-68.
PMID: 26064450
Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence of enhanced vasoconstriction to agonists, thickening of...
4.
Forrest A, Joyce T, Huebner M, Ayon R, Wiwchar M, Joyce J, et al.
Am J Physiol Cell Physiol
. 2012 Oct;
303(12):C1229-43.
PMID: 23034390
Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca(2+) levels in pulmonary hypertension (PH). Whether the functional properties and expression of Ca(2+)-activated Cl- channels (Cl(Ca)), an...
5.
Davis A, Forrest A, Jepps T, Valencik M, Wiwchar M, Singer C, et al.
Am J Physiol Cell Physiol
. 2010 Aug;
299(5):C948-59.
PMID: 20686072
Recently, overexpression of the genes TMEM16A and TMEM16B has been shown to produce currents qualitatively similar to native Ca(2+)-activated Cl(-) currents (I(ClCa)) in vascular smooth muscle. However, there is no...
6.
Mohammed S, Ohtani T, Korinek J, Lam C, Larsen K, Simari R, et al.
Circulation
. 2010 Jul;
122(4):370-8.
PMID: 20625113
Background: Mechanisms promoting the transition from hypertensive heart disease to heart failure with preserved ejection fraction are poorly understood. When inappropriate for salt status, mineralocorticoid (deoxycorticosterone acetate) excess causes hypertrophy,...
7.
Neveux I, Doe J, Leblanc N, Valencik M
Am J Physiol Cell Physiol
. 2010 Feb;
298(5):C1006-17.
PMID: 20164377
The purpose of this study was to determine whether extracellular matrix (ECM) composition through integrin receptors modulated the volume-sensitive osmolyte anion channels (VSOACs) in skeletal muscle-derived C2C12 cells. Cl(-) currents...
8.
Lee H, Chen Q, Wolfram J, Richardson S, Liner A, Siedlak S, et al.
PLoS One
. 2009 Sep;
4(9):e7172.
PMID: 19779629
While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a "fetal re-expression" pattern, the functional role of Myc in mechanisms of...
9.
Ayon R, Sones W, Forrest A, Wiwchar M, Valencik M, Sanguinetti A, et al.
J Biol Chem
. 2009 Sep;
284(47):32507-21.
PMID: 19767392
The present study was undertaken to determine whether the two ubiquitously expressed Ca(2+)-independent phosphatases PP1 and PP2A regulate Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) elicited by 500 nM [Ca(2+)](i) in rabbit pulmonary...
10.
Hunter C, Evans J, Valencik M
Cell Commun Adhes
. 2008 Nov;
15(3):247-60.
PMID: 18979294
Yeast two-hybrid analysis (Fields and Song, 1989, Nature, 340:245-246) was used to screen a human heart library to isolate proteins interacting with the adult muscle-specific beta1D integrin but not with...