Maria Cecilia Fernandes
Overview
Explore the profile of Maria Cecilia Fernandes including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
690
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Recent Articles
1.
Fernandes M, Dillon L, Belew A, Corrada Bravo H, Mosser D, El-Sayed N
mBio
. 2016 May;
7(3).
PMID: 27165796
Unlabelled: Macrophages are mononuclear phagocytes that constitute a first line of defense against pathogens. While lethal to many microbes, they are the primary host cells of Leishmania spp. parasites, the...
2.
Dillon L, Okrah K, Hughitt V, Suresh R, Li Y, Fernandes M, et al.
Nucleic Acids Res
. 2015 Jul;
43(14):6799-813.
PMID: 26150419
Protozoan parasites of the genus Leishmania are the etiological agents of leishmaniasis, a group of diseases with a worldwide incidence of 0.9-1.6 million cases per year. We used RNA-seq to...
3.
The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds
Fernandes M, Corrotte M, Miguel D, Tam C, Andrews N
J Cell Sci
. 2014 Nov;
128(1):27-32.
PMID: 25380822
The process of host cell invasion by Trypanosoma cruzi shares mechanistic elements with plasma membrane injury and repair. Both processes require Ca(2+)-triggered exocytosis of lysosomes, exocytosis of acid sphingomyelinase and...
4.
Corrotte M, Almeida P, Tam C, Castro-Gomes T, Fernandes M, Millis B, et al.
Elife
. 2013 Sep;
2:e00926.
PMID: 24052812
Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are particularly susceptible to injury, and defective sarcolemma resealing causes muscular dystrophy. Caveolae accumulate in dystrophic muscle...
5.
Fernandes M, Flannery A, Andrews N, Mortara R
Cell Microbiol
. 2012 Dec;
15(6):977-91.
PMID: 23241026
The protozoan parasite Trypanosoma cruzi, the aetiological agent of Chagas' disease, has two infective life cycle stages, trypomastigotes and amastigotes. While trypomastigotes actively enter mammalian cells, highly infective extracellular amastigotes...
6.
Fernandes M, Andrews N
FEMS Microbiol Rev
. 2012 Feb;
36(3):734-47.
PMID: 22339763
The intracellular protozoan parasite Trypanosoma cruzi is the causative agent of Chagas' disease, a serious disorder that affects millions of people in Latin America. Despite the development of lifelong immunity...
7.
Fernandes M, de Andrade L, Andrews N, Mortara R
Mem Inst Oswaldo Cruz
. 2012 Jan;
106(8):1014-6.
PMID: 22241126
It has been recently shown that Trypanosoma cruzi trypomastigotes subvert a constitutive membrane repair mechanism to invade HeLa cells. Using a membrane extraction protocol and high-resolution microscopy, the HeLa cytoskeleton...
8.
Toxin pores endocytosed during plasma membrane repair traffic into the lumen of MVBs for degradation
Corrotte M, Fernandes M, Tam C, Andrews N
Traffic
. 2012 Jan;
13(3):483-94.
PMID: 22212686
Cells permeabilized by the bacterial pore-forming toxin streptolysin O (SLO) reseal their plasma membrane in a Ca(2+) -dependent manner. Resealing involves Ca(2+) -dependent exocytosis of lysosomes, release of acid sphingomyelinase...
9.
Cortez M, Huynh C, Fernandes M, Kennedy K, Aderem A, Andrews N
Cell Host Microbe
. 2011 Jun;
9(6):463-71.
PMID: 21669395
Leishmania parasites infect macrophages, cells normally involved in innate defense against pathogens. Leishmania amazonensis and Leishmania major cause severe or mild disease, respectively, consistent with each parasite's ability to survive...
10.
Fernandes M, Cortez M, Flannery A, Tam C, Mortara R, Andrews N
J Exp Med
. 2011 May;
208(5):909-21.
PMID: 21536739
Upon host cell contact, the protozoan parasite Trypanosoma cruzi triggers cytosolic Ca(2+) transients that induce exocytosis of lysosomes, a process required for cell invasion. However, the exact mechanism by which...