Maria Caterina De Rosa
Overview
Explore the profile of Maria Caterina De Rosa including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
128
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Recent Articles
1.
Al-Dalahmah O, Lam M, McInvale J, Qu W, Nguyen T, Mun J, et al.
Cell Stem Cell
. 2024 Apr;
31(5):676-693.e10.
PMID: 38626772
Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain...
2.
Pahl M, Doege C, Hodge K, Littleton S, Leonard M, Lu S, et al.
Nat Commun
. 2021 Nov;
12(1):6749.
PMID: 34799566
The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine systems. Given its role governing key traits, such as body weight and reproductive timing, understanding the genetic regulation of hypothalamic...
3.
De Rosa M, Glover H, Stratigopoulos G, LeDuc C, Su Q, Shen Y, et al.
JCI Insight
. 2021 Jul;
6(16).
PMID: 34283813
Energy balance is controlled by interconnected brain regions in the hypothalamus, brainstem, cortex, and limbic system. Gene expression signatures of these regions can help elucidate the pathophysiology underlying obesity. RNA...
4.
Wang L, Liu Y, Stratigopoulos G, Panigrahi S, Sui L, Zhang Y, et al.
J Clin Invest
. 2021 Feb;
131(8).
PMID: 33630762
Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder caused by mutations in genes encoding components of the primary cilium and is characterized by hyperphagic obesity. To investigate the molecular...
5.
Quarta C, Fisette A, Xu Y, Collden G, Legutko B, Tseng Y, et al.
Nat Metab
. 2020 Jul;
1(2):222-235.
PMID: 32694784
Heterogeneous populations of hypothalamic neurons orchestrate energy balance via the release of specific signatures of neuropeptides. However, how specific intracellular machinery controls peptidergic identities and function of individual hypothalamic neurons...
6.
De Rosa M, Chesi A, McCormack S, Zhou J, Weaver B, McDonald M, et al.
J Clin Endocrinol Metab
. 2019 Feb;
104(7):2961-2970.
PMID: 30811542
Context: Mutations in melanocortin receptor (MC4R) are the most common cause of monogenic obesity in children of European ancestry, but little is known about their prevalence in children from the...
7.
Wang L, De Solis A, Goffer Y, Birkenbach K, Engle S, Tanis R, et al.
JCI Insight
. 2019 Feb;
4(3).
PMID: 30728336
Intronic polymorphisms in the α-ketoglutarate-dependent dioxygenase gene (FTO) that are highly associated with increased body weight have been implicated in the transcriptional control of a nearby ciliary gene, retinitis pigmentosa...
8.
Stratigopoulos G, De Rosa M, LeDuc C, Leibel R, Doege C
PLoS One
. 2018 Jun;
13(6):e0198637.
PMID: 29864154
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein-9 (Cas9) has become the tool of choice for genome editing. Despite the fact that it has evolved as a highly efficient means...
9.
Millings E, De Rosa M, Fleet S, Watanabe K, Rausch R, Egli D, et al.
PLoS One
. 2018 May;
13(5):e0197548.
PMID: 29847571
We have previously reported that Ildr2 knockdown via adenovirally-delivered shRNA causes hepatic steatosis in mice. In the present study we investigated hepatic biochemical and anatomic phenotypes of Cre-mediated Ildr2 knock-out...
10.
De Rosa M, Caputo M, Zirpoli H, Rescigno T, Tarallo R, Giurato G, et al.
J Cell Physiol
. 2015 Feb;
230(9):2059-66.
PMID: 25639214
Serum composition is linked to metabolic diseases not only to understand their pathogenesis but also for diagnostic purposes. Quality and quantity of nutritional intake can affect disease risk and serum...