Mari B Ishak Gabra
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Explore the profile of Mari B Ishak Gabra including associated specialties, affiliations and a list of published articles.
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9
Citations
486
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Recent Articles
1.
Hanse E, Pan M, Liu W, Yang Y, Ishak Gabra M, Tran T, et al.
EMBO Rep
. 2021 Jul;
22(8):e51910.
PMID: 34232566
Adipose tissue plays a major role in maintaining organismal metabolic equilibrium. Control over the fate decision from mesenchymal stem cells (MSCs) to adipocyte differentiation involves coordinated command of phosphorylation. Protein...
2.
Tran T, Hanse E, Habowski A, Li H, Ishak Gabra M, Yang Y, et al.
Nat Cancer
. 2020 Aug;
1(3):345-358.
PMID: 32832918
Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental glutamine restriction further augments Wnt signaling in APC mutant...
3.
Ishak Gabra M, Yang Y, Li H, Senapati P, Hanse E, Lowman X, et al.
Nat Commun
. 2020 Jul;
11(1):3326.
PMID: 32620791
Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor microenvironment remain unexplored. In melanoma, tumour cells often experience low glutamine levels, which promote cell dedifferentiation....
4.
Davis R, Blake K, Ma D, Ishak Gabra M, Hernandez G, Phung A, et al.
Nat Cell Biol
. 2020 Mar;
22(3):310-320.
PMID: 32144411
Although metastasis remains the cause of most cancer-related mortality, mechanisms governing seeding in distal tissues are poorly understood. Here, we establish a robust method for the identification of global transcriptomic...
5.
Lowman X, Hanse E, Yang Y, Ishak Gabra M, Tran T, Li H, et al.
Cell Rep
. 2019 Mar;
26(11):3051-3060.e4.
PMID: 30865893
Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of glutamine, cancer cells frequently undergo glutamine...
6.
Yang Y, Ishak Gabra M, Hanse E, Lowman X, Tran T, Li H, et al.
Nat Commun
. 2019 Feb;
10(1):809.
PMID: 30778058
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which PDAC cells undergo metabolic reprogramming to adapt...
7.
Ishak Gabra M, Yang Y, Lowman X, Reid M, Tran T, Kong M
Oncogenesis
. 2018 Nov;
7(11):93.
PMID: 30478303
One of the hallmarks of cancer is the ability to reprogram cellular metabolism to increase the uptake of necessary nutrients such as glucose and glutamine. Driven by oncogenes, cancer cells...
8.
Tran T, Ishak Gabra M, Lowman X, Yang Y, Reid M, Pan M, et al.
PLoS Biol
. 2017 Nov;
15(11):e2002810.
PMID: 29107960
Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect...
9.
Reid M, Lowman X, Pan M, Tran T, Warmoes M, Ishak Gabra M, et al.
Genes Dev
. 2016 Sep;
30(16):1837-51.
PMID: 27585591
Glutamine is an essential nutrient for cancer cell survival and proliferation. Enhanced utilization of glutamine often depletes its local supply, yet how cancer cells adapt to low glutamine conditions is...