Margus Varjak
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Explore the profile of Margus Varjak including associated specialties, affiliations and a list of published articles.
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35
Citations
1263
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Recent Articles
1.
Dummunee K, Parry R, Redecke L, Varjak M, Brennan B, Kohl A, et al.
J Biol Chem
. 2025 Feb;
:108332.
PMID: 39984048
Viruses transmitted by biting arthropods, arboviruses, pose a significant global health and economic threat. Climate change is exacerbating this issue by expanding the range of disease-carrying vectors. Effective control of...
2.
Reuter M, Parry R, McDonald M, Gestuveo R, Arif R, Khromykh A, et al.
RNA
. 2025 Feb;
PMID: 39947927
The exogenous siRNA (exo-siRNA) pathway is a critical RNA interference response involved in controlling arbovirus replication in mosquito cells. It is initiated by the detection of viral long double-stranded RNA...
3.
Jiang Z, Merits A, Qin Y, Xing G, Zhang L, Chen J, et al.
PLoS Pathog
. 2024 Nov;
20(11):e1012700.
PMID: 39556619
Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses and piglets; it also poses a potential threat to...
4.
Pinto R, Bakshi S, Lytras S, Zakaria M, Swingler S, Worrell J, et al.
Nature
. 2023 Jun;
619(7969):338-347.
PMID: 37380775
Spillover events of avian influenza A viruses (IAVs) to humans could represent the first step in a future pandemic. Several factors that limit the transmission and replication of avian IAVs...
5.
Hardy A, Bakshi S, Furnon W, MacLean O, Gu Q, Varjak M, et al.
mBio
. 2023 Apr;
14(3):e0010123.
PMID: 37097030
Infected hosts possess two alternative strategies to protect themselves against the negative impact of virus infections: resistance, used to abrogate virus replication, and disease tolerance, used to avoid tissue damage...
6.
Alexander A, Salvemini M, Sreenu V, Hughes J, Telleria E, Ratinier M, et al.
PLoS Pathog
. 2023 Mar;
19(3):e1011283.
PMID: 36996243
Toscana virus (TOSV) (Bunyavirales, Phenuiviridae, Phlebovirus, Toscana phlebovirus) and other related human pathogenic arboviruses are transmitted by phlebotomine sand flies. TOSV has been reported in nations bordering the Mediterranean Sea...
7.
Lefteri D, Bryden S, Pingen M, Terry S, McCafferty A, Beswick E, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2114309119.
PMID: 35675424
Viruses transmitted by mosquitoes are an increasingly important global cause of disease. Defining common determinants of host susceptibility to this large group of heterogenous pathogens is key for informing the...
8.
Gestuveo R, Parry R, Dickson L, Lequime S, Sreenu V, Arnold M, et al.
PLoS Pathog
. 2022 Jan;
18(1):e1010202.
PMID: 34990484
The exogenous small interfering RNA (exo-siRNA) pathway is a key antiviral mechanism in the Aedes aegypti mosquito, a widely distributed vector of human-pathogenic arboviruses. This pathway is induced by virus-derived...
9.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull M, et al.
Science
. 2021 Sep;
374(6567):eabj3624.
PMID: 34581622
Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and...
10.
Almire F, Terhzaz S, Terry S, McFarlane M, Gestuveo R, Szemiel A, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1009870.
PMID: 34473801
As mosquito females require a blood meal to reproduce, they can act as vectors of numerous pathogens, such as arboviruses (e.g. Zika, dengue and chikungunya viruses), which constitute a substantial...