Margus Leppik
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Explore the profile of Margus Leppik including associated specialties, affiliations and a list of published articles.
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13
Citations
115
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Recent Articles
1.
Leppik M, Pomerants L, Poldes A, Mihkelson P, Remme J, Tamm T
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791231
Ribosomal RNAs (rRNAs) are extensively modified during the transcription and subsequent maturation. Three types of modifications, 2'-O-methylation of ribose moiety, pseudouridylation, and base modifications, are introduced either by a snoRNA-driven...
2.
Ero R, Leppik M, Reier K, Liiv A, Remme J
Nucleic Acids Res
. 2024 Mar;
52(11):6614-6628.
PMID: 38554109
Ribosomal RNA modifications are introduced by specific enzymes during ribosome assembly in bacteria. Deletion of individual modification enzymes has a minor effect on bacterial growth, ribosome biogenesis, and translation, which...
3.
Jurgenstein K, Tagel M, Ilves H, Leppik M, Kivisaar M, Remme J
RNA Biol
. 2022 Sep;
19(1):1050-1058.
PMID: 36093925
Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels. Here,...
4.
Liljeruhm J, Leppik M, Bao L, Truu T, Calvo-Noriega M, Freyer N, et al.
RNA
. 2022 Mar;
28(6):796-807.
PMID: 35260421
rRNAs are post-transcriptionally modified at 36 positions but their modification enzymes are dispensable individually for growth, bringing into question their significance. However, a major growth defect was reported for deletion...
5.
Tagel M, Ilves H, Leppik M, Jurgenstein K, Remme J, Kivisaar M
Microorganisms
. 2020 Dec;
9(1).
PMID: 33374637
Pseudouridines are known to be important for optimal translation. In this study we demonstrate an unexpected link between pseudouridylation of tRNA and mutation frequency in species. We observed that the...
6.
Aleksashin N, Leppik M, Hockenberry A, Klepacki D, Vazquez-Laslop N, Jewett M, et al.
Nat Commun
. 2019 Feb;
10(1):930.
PMID: 30804338
Ribo-T is an engineered ribosome whose small and large subunits are tethered together by linking 16S rRNA and 23S rRNA in a single molecule. Although Ribo-T can support cell proliferation...
7.
OConnor M, Leppik M, Remme J
J Bacteriol
. 2017 Nov;
200(4).
PMID: 29180357
Pseudouridine (Ψ) is present at conserved, functionally important regions in the ribosomal RNAs (rRNAs) from all three domains of life. Little, however, is known about the functions of Ψ modifications...
8.
Leppik M, Liiv A, Remme J
Nucleic Acids Res
. 2017 Mar;
45(10):6098-6108.
PMID: 28334881
Pseudouridine is the most common modified nucleoside in RNA, which is found in stable RNA species and in eukaryotic mRNAs. Functional analysis of pseudouridine is complicated by marginal effect of...
9.
Ainelo A, Tamman H, Leppik M, Remme J, Horak R
Mol Microbiol
. 2016 Feb;
100(4):719-34.
PMID: 26833678
Most bacteria encode numerous chromosomal toxin-antitoxin (TA) systems that are proposed to contribute to stress tolerance, as they are able to shift the cells to a dormant state. Toxins act...
10.
Paier A, Leppik M, Soosaar A, Tenson T, Maivali U
Sci Rep
. 2015 Jan;
5:7712.
PMID: 25578614
Although ribosomes are very stable under most conditions, ribosomal degradation does occur in diverse groups of organisms in response to specific stresses or environmental conditions. While non-functional ribosome decay (NRD)...