Margot J Wyrwoll
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Explore the profile of Margot J Wyrwoll including associated specialties, affiliations and a list of published articles.
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22
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337
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Recent Articles
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Wyrwoll M, Steingrover J
Med Genet
. 2024 Sep;
36(3):179-188.
PMID: 39257928
For those affected, infertility is linked to impaired overall health and reduced life expectancy. In particular, infertile individuals bear an increased risk for cardiovascular disease (CVD) and different types of...
3.
Stallmeyer B, Buhlmann C, Stakaitis R, Dicke A, Ghieh F, Meier L, et al.
Nat Commun
. 2024 Aug;
15(1):6637.
PMID: 39122675
piRNAs are crucial for transposon silencing, germ cell maturation, and fertility in male mice. Here, we report on the genetic landscape of piRNA dysfunction in humans and present 39 infertile...
4.
Wyrwoll M, Rudnik-Schoneborn S, Tuttelmann F
Med Genet
. 2024 Jun;
33(1):3-12.
PMID: 38836211
Around 10-15 % of all couples are infertile, rendering infertility a widespread disease. Male and female causes contribute equally to infertility, and, depending on the definition, roughly 1 % to...
5.
Lahtinen A, Funke M, Krallmann C, Wyrwoll M, Jarisch A, Yang Y, et al.
Br J Haematol
. 2024 May;
205(1):229-235.
PMID: 38810989
This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation....
6.
Gargano M, Matentzoglu N, Coleman B, Addo-Lartey E, Anagnostopoulos A, Anderton J, et al.
Nucleic Acids Res
. 2023 Nov;
52(D1):D1333-D1346.
PMID: 37953324
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses...
7.
Wyrwoll M, van der Heijden G, Krausz C, Aston K, Kliesch S, McLachlan R, et al.
Nat Rev Urol
. 2023 Sep;
21(2):91-101.
PMID: 37723288
An increasing number of genes are being described in the context of non-syndromic male infertility. Linking the underlying genetic causes of non-syndromic male infertility with clinical data from patients is...
8.
Sieper M, Gaikwad A, Fros M, Weber P, Di Persio S, Oud M, et al.
Andrology
. 2023 Aug;
12(3):570-584.
PMID: 37594251
Background: Infertility affects around 15% of all couples worldwide and is increasingly linked to variants in genes specifically expressed in the testis. Well-established causes of male infertility include pathogenic variants...
9.
Dicke A, Albrethsen J, Hoare B, Wyrwoll M, Busch A, Fietz D, et al.
Hum Reprod
. 2023 May;
38(7):1412-1423.
PMID: 37208861
Study Question: What is the impact of variants in the genes INSL3 (Insulin Like 3) and RXFP2 (Relaxin Family Peptide Receptor 2), respectively, on cryptorchidism and male infertility? Summary Answer:...
10.
Hoffken V, Di Persio S, Laurentino S, Wyrwoll M, Terwort N, Hermann A, et al.
FASEB J
. 2023 Apr;
37(5):e22912.
PMID: 37086090
The family of WWC proteins is known to regulate cell proliferation and organ growth control via the Hippo signaling pathway. As WWC proteins share a similar domain structure and a...