Reproductive Genetics and Health

Overview

Journal Med Genet

Publisher De Gruyter

Specialties Genetics
Medical Ethics

Date 2024 Sep 11

PMID 39257928

Authors

Margot J Wyrwoll

Johanna Steingrover

Affiliations

Soon will be listed here.

Abstract

For those affected, infertility is linked to impaired overall health and reduced life expectancy. In particular, infertile individuals bear an increased risk for cardiovascular disease (CVD) and different types of cancer, partially due to lifestyle differences and to genetic alterations that cause both infertility and an increased cancer risk. Genetic variants causing an increased CVD risk are more commonly found in infertile individuals, but their link to infertility remains unclear. Offspring of infertile couples, conceived via medically assisted reproduction, are as likely as their parents to exhibit or develop adiposity, hormonal alterations such as insulin resistance, and infertility. The effects on health of subsequent generations are completely unclear.

References

Morozumi K, Yanagimachi R . Incorporation of the acrosome into the oocyte during intracytoplasmic sperm injection could be potentially hazardous to embryo development. Proc Natl Acad Sci U S A. 2005; 102(40):14209-14. PMC: 1242329. DOI: 10.1073/pnas.0507005102. View

Nagirnaja L, Aston K, Conrad D . Genetic intersection of male infertility and cancer. Fertil Steril. 2018; 109(1):20-26. PMC: 5761685. DOI: 10.1016/j.fertnstert.2017.10.028. View

Wallmeier J, Nielsen K, Kuehni C, Lucas J, Leigh M, Zariwala M . Motile ciliopathies. Nat Rev Dis Primers. 2020; 6(1):77. DOI: 10.1038/s41572-020-0209-6. View

Catford S, McLachlan R, OBryan M, Halliday J . Long-term follow-up of ICSI-conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology. 2018; 6(5):635-653. DOI: 10.1111/andr.12526. View

Senapati S . Infertility: a marker of future health risk in women?. Fertil Steril. 2018; 110(5):783-789. DOI: 10.1016/j.fertnstert.2018.08.058. View

Shoemark A, Harman K . Primary Ciliary Dyskinesia. Semin Respir Crit Care Med. 2021; 42(4):537-548. DOI: 10.1055/s-0041-1730919. View

Lewon M, Wang Y, Peters C, Peterson M, Zheng H, Wang Z . Assessment of operant learning and memory in mice born through ICSI. Hum Reprod. 2020; 35(9):2058-2071. PMC: 7485617. DOI: 10.1093/humrep/deaa167. View

James E, Jenkins T . Epigenetics, infertility, and cancer: future directions. Fertil Steril. 2018; 109(1):27-32. DOI: 10.1016/j.fertnstert.2017.11.006. View

Tarin J, Garcia-Perez M, Hamatani T, Cano A . Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases. Reprod Biol Endocrinol. 2015; 13:31. PMC: 4404574. DOI: 10.1186/s12958-015-0029-9. View

10.

Randeva H, Tan B, Weickert M, Lois K, Nestler J, Sattar N . Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev. 2012; 33(5):812-41. PMC: 3461136. DOI: 10.1210/er.2012-1003. View

11.

Lacamara C, Ortega C, Villa S, Pommer R, Schwarze J . Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis. JBRA Assist Reprod. 2017; 21(3):251-259. PMC: 5574649. DOI: 10.5935/1518-0557.20170047. View

12.

Ventimiglia E, Capogrosso P, Boeri L, Serino A, Colicchia M, Ippolito S . Infertility as a proxy of general male health: results of a cross-sectional survey. Fertil Steril. 2015; 104(1):48-55. DOI: 10.1016/j.fertnstert.2015.04.020. View

13.

Liu L, Gao J, He X, Cai Y, Wang L, Fan X . Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis. Sci Rep. 2017; 7:46207. PMC: 5384197. DOI: 10.1038/srep46207. View

14.

Zhang N, Tian T, Li J, Zhu X, Jiesisibieke D, Fang S . A comparison of pregnancy outcomes and congenital malformations in offspring between patients undergoing intracytoplasmic sperm injection and conventional in vitro fertilization: a retrospective cohort study. Fertil Steril. 2024; 121(6):982-990. DOI: 10.1016/j.fertnstert.2024.01.025. View

15.

Cui L, Zhou W, Xi B, Ma J, Hu J, Fang M . Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology. Diabetologia. 2020; 63(10):2150-2157. DOI: 10.1007/s00125-020-05241-1. View

16.

Wang Y, Farland L, Wang S, Gaskins A, Wang L, Rich-Edwards J . Association of infertility with premature mortality among US women: Prospective cohort study. Lancet Reg Health Am. 2022; 7. PMC: 9004660. DOI: 10.1016/j.lana.2021.100122. View

17.

Turan V, Oktay K . BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. Hum Reprod Update. 2019; 26(1):43-57. PMC: 6935693. DOI: 10.1093/humupd/dmz043. View

18.

Singh P, Fragoza R, Blengini C, Tran T, Pannafino G, Al-Sweel N . Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging. Nat Commun. 2021; 12(1):5005. PMC: 8373927. DOI: 10.1038/s41467-021-25028-1. View

19.

Hotaling J, Laufer N, Rosenwaks Z . Introduction: Cancer biomarkers and fertility. Fertil Steril. 2018; 109(1):4-5. DOI: 10.1016/j.fertnstert.2017.12.009. View

20.

Wyns C, De Geyter C, Calhaz-Jorge C, Kupka M, Motrenko T, Smeenk J . ART in Europe, 2017: results generated from European registries by ESHRE. Hum Reprod Open. 2021; 2021(3):hoab026. PMC: 8342033. DOI: 10.1093/hropen/hoab026. View