Margarida Cardoso-Moreira
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Explore the profile of Margarida Cardoso-Moreira including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Sepp M, Leiss K, Murat F, Okonechnikov K, Joshi P, Leushkin E, et al.
Nature
. 2023 Nov;
625(7996):788-796.
PMID: 38029793
The expansion of the neocortex, a hallmark of mammalian evolution, was accompanied by an increase in cerebellar neuron numbers. However, little is known about the evolution of the cellular programmes...
2.
Rodriguez-Montes L, Ovchinnikova S, Yuan X, Studer T, Sarropoulos I, Anders S, et al.
Science
. 2023 Nov;
382(6670):eadf1046.
PMID: 37917687
Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using...
3.
Murat F, Mbengue N, Boeg Winge S, Trefzer T, Leushkin E, Sepp M, et al.
Nature
. 2022 Dec;
613(7943):308-316.
PMID: 36544022
The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals, probably owing to the evolutionary pressure on males to be reproductively successful....
4.
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
Muller M, Eghbalian R, Boeckel J, Frese K, Haas J, Kayvanpour E, et al.
Nat Commun
. 2022 Oct;
13(1):6209.
PMID: 36266340
To adapt to changing hemodynamic demands, regulatory mechanisms modulate actin-myosin-kinetics by calcium-dependent and -independent mechanisms. We investigate the posttranslational modification of human essential myosin light chain (ELC) and identify NIMA-related...
5.
Zhang F, Raabe C, Cardoso-Moreira M, Brosius J, Kaessmann H, Schmitz J
Genomics
. 2022 Jul;
114(4):110434.
PMID: 35863675
Advances in RNA high-throughput sequencing and large-scale functional assays yield new insights into the multifaceted activities of transposed elements (TE) and many other previously undiscovered sequence elements. Currently, no tool...
6.
Sarropoulos I, Sepp M, Fromel R, Leiss K, Trost N, Leushkin E, et al.
Science
. 2021 Aug;
373(6558).
PMID: 34446581
Organ development is orchestrated by cell- and time-specific gene regulatory networks. In this study, we investigated the regulatory basis of mouse cerebellum development from early neurogenesis to adulthood. By acquiring...
7.
Mazin P, Khaitovich P, Cardoso-Moreira M, Kaessmann H
Nat Genet
. 2021 May;
53(6):925-934.
PMID: 33941934
Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species comparisons have been largely restricted to adult tissues and the functionality of most AS events remains unclear. We assessed AS...
8.
Wang Z, Leushkin E, Liechti A, Ovchinnikova S, Mossinger K, Bruning T, et al.
Nature
. 2020 Nov;
588(7839):642-647.
PMID: 33177713
Gene-expression programs define shared and species-specific phenotypes, but their evolution remains largely uncharacterized beyond the transcriptome layer. Here we report an analysis of the co-evolution of translatomes and transcriptomes using...
9.
Cardoso-Moreira M, Sarropoulos I, Velten B, Mort M, Cooper D, Huber W, et al.
Cell Rep
. 2020 Oct;
33(4):108308.
PMID: 33113372
Identifying the molecular programs underlying human organ development and how they differ from model species is key for understanding human health and disease. Developmental gene expression profiles provide a window...
10.
Cardoso-Moreira M, Halbert J, Valloton D, Velten B, Chen C, Shao Y, et al.
Nature
. 2019 Jun;
571(7766):505-509.
PMID: 31243369
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental...