Margareta T Wilhelm
Overview
Explore the profile of Margareta T Wilhelm including associated specialties, affiliations and a list of published articles.
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10
Citations
357
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Recent Articles
1.
Wolfsberger J, Sakil H, Zhou L, van Bree N, Baldisseri E, de Souza Ferreira S, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(10).
PMID: 33649219
Infiltration of tumor-promoting immune cells is a strong driver of tumor progression. Especially the accumulation of macrophages in the tumor microenvironment is known to facilitate tumor growth and to correlate...
2.
Stantic M, Wolfsberger J, Sakil H, Wilhelm M
Oncogene
. 2018 Apr;
37(27):3729-3739.
PMID: 29628507
Cellular responses to low oxygen conditions are mainly regulated by the Hypoxia-inducible factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows for metabolic adaptations. HIF-1α...
3.
Sakil H, Stantic M, Wolfsberger J, Egyhazi Brage S, Hansson J, Wilhelm M
Cell Oncol (Dordr)
. 2017 Jul;
40(6):631-638.
PMID: 28677036
Purpose: Multidrug resistance (MDR) is a major cause of treatment failure. In cancer cells, MDR is often caused by an increased efflux of therapeutic drugs mediated by an up-regulation of...
4.
Stantic M, Sakil H, Zirath H, Fang T, Sanz G, Fernandez-Woodbridge A, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
112(1):220-5.
PMID: 25535357
The p53-family member TAp73 is known to function as a tumor suppressor and regulates genomic integrity, cellular proliferation, and apoptosis; however, its role in tumor angiogenesis is poorly understood. Here...
5.
Vilborg A, Wilhelm M, Wiman K
J Mol Med (Berl)
. 2010 Mar;
88(7):645-52.
PMID: 20306257
p53 is a key tumor suppressor that triggers cell cycle arrest, senescence, or apoptosis in response to cellular stress. Frequent p53 mutation in human tumors allows survival, sustained growth, and...
6.
Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al.
Genes Dev
. 2010 Mar;
24(6):549-60.
PMID: 20194434
Mice with a complete deficiency of p73 have severe neurological and immunological defects due to the absence of all TAp73 and DeltaNp73 isoforms. As part of our ongoing program to...
7.
Vilborg A, Glahder J, Wilhelm M, Bersani C, Corcoran M, Mahmoudi S, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(37):15756-61.
PMID: 19805223
The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the...
8.
Hall H, Wilhelm M, Saibil S, Mak T, Flavell R, Ohashi P
Eur J Immunol
. 2007 Dec;
38(1):64-72.
PMID: 18085666
Receptor-interacting protein 2 (RIP2), also known as CARDIAK and RICK, has been reported to play a role in both adaptive T cell responses and innate immunity as a mediator in...
9.
Wilhelm M, Mendez-Vidal C, Wiman K
FEBS Lett
. 2002 Jul;
524(1-3):69-72.
PMID: 12135743
We previously identified wig-1 as a p53-induced mouse gene that encodes a nuclear zinc finger protein with unknown function. To investigate whether wig-1 is a direct target of p53-dependent transactivation,...
10.
Mendez-Vidal C, Wilhelm M, Hellborg F, Qian W, Wiman K
Nucleic Acids Res
. 2002 Apr;
30(9):1991-6.
PMID: 11972337
The p53-induced mouse wig-1 gene encodes a Cys2His2-type zinc finger protein of unknown function. The zinc fingers in wig-1 are connected by long (56-75) amino acid linkers. This distribution of...