Margaret M Sedensky
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Explore the profile of Margaret M Sedensky including associated specialties, affiliations and a list of published articles.
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57
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1687
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Recent Articles
1.
Morgan P, Sedensky M
Anesthesiology
. 2024 Sep;
141(4):745-749.
PMID: 39254540
Background: Mutations in several genes of Caenorhabditis elegans confer altered sensitivities to volatile anesthetics. A mutation in one gene, gas-1(fc21), causes animals to be immobilized at lower concentrations of all...
2.
Spencer K, Howe M, Mulholland M, Truong V, Liao R, Chen Y, et al.
Paediatr Anaesth
. 2024 Feb;
34(5):467-476.
PMID: 38358320
Background: Genetic mitochondrial diseases impact over 1 in 4000 individuals, most often presenting in infancy or early childhood. Seizures are major clinical sequelae in some mitochondrial diseases including Leigh syndrome,...
3.
Woods C, Predoi B, Howe M, Reczek C, Kayser E, Ramirez J, et al.
Anesthesiology
. 2023 Dec;
140(4):715-728.
PMID: 38147628
Background: Volatile anesthetics induce hyperpolarizing potassium currents in spinal cord neurons that may contribute to their mechanism of action. They are induced at lower concentrations of isoflurane in noncholinergic neurons...
4.
Perouansky M, Johnson-Schlitz D, Sedensky M, Morgan P
Exp Biol Med (Maywood)
. 2023 May;
248(7):545-552.
PMID: 37208922
One of the unsolved mysteries of medicine is how do volatile anesthetics (VAs) cause a patient to reversibly lose consciousness. In addition, identifying mechanisms for the collateral effects of VAs,...
5.
Spencer K, Woods C, Worstman H, Johnson S, Ramirez J, Morgan P, et al.
Anesthesiology
. 2023 Apr;
139(1):63-76.
PMID: 37027798
Background: A variety of molecular targets for volatile anesthetics have been suggested, including the anesthetic-sensitive potassium leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile...
6.
Jung S, Zimin P, Woods C, Kayser E, Haddad D, Reczek C, et al.
Curr Biol
. 2022 Jun;
32(14):3016-3032.e3.
PMID: 35688155
The mechanisms of volatile anesthetic action remain among the most perplexing mysteries of medicine. Across phylogeny, volatile anesthetics selectively inhibit mitochondrial complex I, and they also depress presynaptic excitatory signaling....
7.
Stokes J, Bornstein R, James K, Park K, Spencer K, Vo K, et al.
JCI Insight
. 2022 Jan;
7(5).
PMID: 35050903
Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been elusive. Here, we report...
8.
Jung S, Kayser E, Johnson S, Li L, Worstman H, Sun G, et al.
Br J Anaesth
. 2021 Dec;
128(1):77-88.
PMID: 34857359
Background: If anaesthetics cause permanent cognitive deficits in some children, the implications are enormous, but the molecular causes of anaesthetic-induced neurotoxicity, and consequently possible therapies, are still debated. Anaesthetic exposure...
9.
Stokes J, Freed A, Bornstein R, Su K, Snell J, Pan A, et al.
Elife
. 2021 Jul;
10.
PMID: 34254587
Volatile anesthetics (VAs) are widely used in medicine, but the mechanisms underlying their effects remain ill-defined. Though routine anesthesia is safe in healthy individuals, instances of sensitivity are well documented,...
10.
Woods C, Spencer K, Jung S, Worstman H, Ramirez J, Morgan P, et al.
Anesthesiology
. 2021 Apr;
134(6):901-914.
PMID: 33909880
Background: Ndufs4 knockout (KO) mice are defective in mitochondrial complex I function and hypersensitive to inhibition of spinal cord-mediated response to noxious stimuli by volatile anesthetics. It was hypothesized that,...