Margaret Leversha
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Explore the profile of Margaret Leversha including associated specialties, affiliations and a list of published articles.
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7
Citations
1871
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Recent Articles
1.
Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris P, et al.
Cell
. 2012 Jul;
150(1):165-78.
PMID: 22770218
Metastasis and chemoresistance in cancer are linked phenomena, but the molecular basis for this link is unknown. We uncovered a network of paracrine signals between carcinoma, myeloid, and endothelial cells...
2.
Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga K, Geber A, et al.
Nature
. 2010 Nov;
468(7325):829-33.
PMID: 21102433
Glioblastoma (GBM) is among the most aggressive of human cancers. A key feature of GBMs is the extensive network of abnormal vasculature characterized by glomeruloid structures and endothelial hyperplasia. Yet...
3.
Liu Y, Yeh N, Zhu X, Leversha M, Cordon-Cardo C, Ghossein R, et al.
EMBO J
. 2007 Oct;
26(22):4683-93.
PMID: 17948060
How proteins participate in tumorigenesis can be obscured by their multifunctional nature. For example, depending on the cellular context, the cdk inhibitors can affect cell proliferation, cell motility, apoptosis, receptor...
4.
Avital I, Moreira A, Klimstra D, Leversha M, Papadopoulos E, Brennan M, et al.
Stem Cells
. 2007 Aug;
25(11):2903-9.
PMID: 17690178
Bone marrow-derived stem cells have been shown to participate in solid organ repair after tissue injury. Animal models suggest that epithelial malignancies may arise as aberrant stem cell differentiation during...
5.
Eladad S, Ye T, Hu P, Leversha M, Beresten S, Matunis M, et al.
Hum Mol Genet
. 2005 Apr;
14(10):1351-65.
PMID: 15829507
The Bloom syndrome gene, BLM, encodes a RecQ DNA helicase that when absent from the cell results in genomic instability and cancer predisposition. We show here that BLM is a...
6.
Ross M, Grafham D, Coffey A, Scherer S, McLay K, Muzny D, et al.
Nature
. 2005 Mar;
434(7031):325-37.
PMID: 15772651
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic...
7.
Shaffer D, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, et al.
Proc Natl Acad Sci U S A
. 2004 Dec;
102(1):210-5.
PMID: 15615849
Reduced p27 levels correlate with poor prognosis in a wide spectrum of human tumors and can accelerate tumorigenesis in mouse tissues. To determine whether p27 deficiency can accelerate tumorigenesis in...