Marek Krol
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Explore the profile of Marek Krol including associated specialties, affiliations and a list of published articles.
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38
Citations
302
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Recent Articles
1.
Kalucka M, Roszczyk A, Klimaszewska M, Kaleta B, Drelich E, Blazewicz A, et al.
Nutrients
. 2023 Sep;
15(18).
PMID: 37764798
Mycelial cultures of , an edible and medicinal mushroom, have been used in our previous research to obtain selenium-containing immunomodulatory preparations. Our current attempts to obtain a new preparation containing...
2.
Krol M, Slifirski G, Kleps J, Podsadni P, Materek I, Koziol A, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613958
This article describes the synthesis of new chiral 3-(piperidin-3-yl)-1H-indole derivatives and from the corresponding diastereomers: (3R, 2R) and (3S, 2R)-2-[3-(1H-indol-3-yl)-1-piperidyl]-2-phenyl-acetamides and . Diastereomers were obtained by N-alkylation of derivatives of...
3.
Slifirski G, Krol M, Turlo J
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445721
Serotonin modulates several physiological and cognitive pathways throughout the human body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the serotonergic system and interactions with other...
4.
Krol M, Slifirski G, Kleps J, Ulenberg S, Belka M, Baczek T, et al.
Int J Mol Sci
. 2021 Mar;
22(5).
PMID: 33652672
Two series of novel 4-aryl-2H-pyrido[1,2-c]pyrimidine (6a-i) and 4-aryl-5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine () derivatives were synthesized. The chemical structures of the new compounds were confirmed by H and C NMR spectroscopy and ESI-HRMS spectrometry....
5.
Ulenberg S, Georgiev P, Belka M, Slifirski G, Wrobel M, Chodkowski A, et al.
J Chromatogr A
. 2020 Aug;
1629:461501.
PMID: 32841768
Metabolic stability tests are one of the fundamental steps at the preclinical stages of new drug development. Microsomes, used as a typical enzymatic model of liver biotransformation, can be a...
6.
Janas A, Krol M, Hochul M, Jochymczyk M, Hayward-Costa C, Parise H, et al.
J Clin Med
. 2020 Jun;
9(6).
PMID: 32560164
Catheter-based renal denervation (RDN) has been investigated for hypertension (HTN) treatment with variable success. One of the novel approaches to RDN is the delivery of micro-doses of dehydrated alcohol to...
7.
Dawidowski M, Krol M, Szulczyk B, Chodkowski A, Podsadni P, Konopelski P, et al.
Bioorg Chem
. 2020 Mar;
98:103717.
PMID: 32171994
A series of 2-aryl-2-(pyridin-2-yl)acetamides were synthesized and screened for their anticonvulsant activity in animal models of epilepsy. The compounds were broadly active in the 'classical' maximal electroshock seizure (MES) and...
8.
Slifirski G, Krol M, Kleps J, Podsadni P, Belka M, Baczek T, et al.
Eur J Med Chem
. 2019 Jul;
180:383-397.
PMID: 31325785
Extended studies in the 4-aryl-pyrido[1,2-c]pyrimidine group resulted in 27 new compounds (10.1-10.27), 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives. In vitro tests (RBA) were carried out for 10.1-10.27 compounds in order to determine their affinity...
9.
Ulenberg S, Baczek T, Zielinska J, Belka M, Krol M, Herold F
Comb Chem High Throughput Screen
. 2019 Jul;
22(6):370-378.
PMID: 31284855
Background: Molecular docking has often been used before to calculate in silico affinity of drugs towards their molecular target, but not to estimate leading CYP isoform responsible for metabolism of...
10.
Slifirski G, Krol M, Kleps J, Ulenberg S, Belka M, Baczek T, et al.
Eur J Med Chem
. 2019 Feb;
166:144-158.
PMID: 30703658
The study enabled obtaining a number of new derivatives of 4-aryl-pyrido[1,2-c]pyrimidine 9.1-9.27 having conformationally restricted tryptamine moiety. In vitro studies (RBA) have shown that derivatives 9.1, 9.2, 9.4, 9.7, 9.9,...