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Marcus Valentine

Explore the profile of Marcus Valentine including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 1621
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Recent Articles
1.
Gao Q, Ryan S, Iacobucci I, Ghate P, Cranston R, Schwab C, et al.
Blood . 2023 May; 142(8):711-723. PMID: 37216686
Intrachromosomal amplification of chromosome 21 defines a subtype of high-risk childhood acute lymphoblastic leukemia (iAMP21-ALL) characterized by copy number changes and complex rearrangements of chromosome 21. The genomic basis of...
2.
Abdelhamed S, Thomas 3rd M, Westover T, Umeda M, Xiong E, Rolle C, et al.
J Clin Invest . 2022 Sep; 132(21). PMID: 36074606
SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have impaired hematopoiesis, hypocellular marrows, and a greater risk of...
3.
Brimble M, Cheng P, Winston S, Reeves I, Souquette A, Spence Y, et al.
Mol Ther Methods Clin Dev . 2022 Feb; 24:280-291. PMID: 35211640
Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer...
4.
Iacobucci I, Wen J, Meggendorfer M, Choi J, Shi L, Pounds S, et al.
Nat Genet . 2019 Mar; 51(4):694-704. PMID: 30926971
Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of...
5.
Graetz D, Crews K, Azzato E, Singh R, Raimondi S, Mason J, et al.
Haematologica . 2019 Mar; 104(5):e218-e221. PMID: 30819904
No abstract available.
6.
Alexander T, Gu Z, Iacobucci I, Dickerson K, Choi J, Xu B, et al.
Nature . 2018 Sep; 562(7727):373-379. PMID: 30209392
Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid and lymphoid features, limited genetic characterization, and a lack of consensus regarding appropriate therapy. Here we show...
7.
Jain N, Lu X, Daver N, Thakral B, Wang S, Konoplev S, et al.
Haematologica . 2017 Sep; 102(12):e514-e517. PMID: 28860345
No abstract available.
8.
Jain N, Roberts K, Jabbour E, Patel K, Eterovic A, Chen K, et al.
Blood . 2016 Dec; 129(5):572-581. PMID: 27919910
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients...
9.
Roberts K, Gu Z, Payne-Turner D, McCastlain K, Harvey R, Chen I, et al.
J Clin Oncol . 2016 Nov; 35(4):394-401. PMID: 27870571
Purpose Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtype of childhood ALL characterized by kinase-activating alterations that are amenable to treatment with tyrosine kinase inhibitors. We...
10.
Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey R, et al.
Nat Commun . 2016 Nov; 7:13331. PMID: 27824051
Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes...