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Marcus O W Grimm

Explore the profile of Marcus O W Grimm including associated specialties, affiliations and a list of published articles. Areas
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Articles 47
Citations 1522
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Recent Articles
1.
Lauer A, Nguyen V, Janitschke D, Guilherme M, Bachmann C, Grimm H, et al.
Int J Mol Sci . 2022 Dec; 23(24). PMID: 36555176
Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults...
2.
Lyschik S, Lauer A, Roth T, Janitschke D, Hollander M, Will T, et al.
Front Cell Dev Biol . 2022 May; 10:859052. PMID: 35557938
Cellular lipid metabolism is tightly regulated and requires a sophisticated interplay of multiple subcellular organelles to adapt to changing nutrient supply. PEX19 was originally described as an essential peroxisome biogenesis...
3.
Mett J, Lauer A, Janitschke D, Griebsch L, Theiss E, Grimm H, et al.
Cells . 2021 Nov; 10(11). PMID: 34831163
The accumulation of amyloid β-protein (Aβ) is one of the major pathological hallmarks of Alzheimer's disease. Insulin-degrading enzyme (IDE), a zinc-metalloprotease, is a key enzyme involved in Aβ degradation, which,...
4.
Lauer A, Janitschke D, Guilherme M, Nguyen V, Bachmann C, Qiao S, et al.
Sci Rep . 2021 Jul; 11(1):15301. PMID: 34315969
Alzheimer's disease (AD) is a very frequent neurodegenerative disorder characterized by an accumulation of amyloid-β (Aβ). Acitretin, a retinoid-derivative and approved treatment for Psoriasis vulgaris, increases non-amyloidogenic Amyloid-Precursor-Protein-(APP)-processing, prevents Aβ-production...
5.
Ramesh G, Jarzembowski L, Schwarz Y, Poth V, Konrad M, Knapp M, et al.
Cell Rep . 2021 Mar; 34(11):108844. PMID: 33730587
Store-operated Ca-entry (SOCE) regulates basal and receptor-triggered Ca signaling with STIM proteins sensing the endoplasmic reticulum (ER) Ca content and triggering Ca entry by gating Orai channels. Although crucial for...
6.
Janitschke D, Lauer A, Bachmann C, Grimm H, Hartmann T, Grimm M
Nutrients . 2021 Mar; 13(3). PMID: 33671099
Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring methylxanthines like caffeine, theophylline or theobromine are widely consumed in food, several synthetic but also non-synthetic methylxanthines are used as...
7.
Janitschke D, Lauer A, Bachmann C, Seyfried M, Grimm H, Hartmann T, et al.
Int J Mol Sci . 2020 Dec; 21(23). PMID: 33260941
Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position...
8.
Lauer A, Mett J, Janitschke D, Thiel A, Stahlmann C, Bachmann C, et al.
Aging Cell . 2020 Oct; 19(11):e13264. PMID: 33128835
One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid-β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques. Under physiological...
9.
Grimm M, Blumel T, Lauer A, Janitschke D, Stahlmann C, Mett J, et al.
Sci Rep . 2020 Jun; 10(1):9164. PMID: 32514053
The vanilloid capsaicin is a widely consumed spice, known for its burning and "hot" sensation through activation of TRPV1 ion-channels, but also known to decrease oxidative stress, inflammation and influence...
10.
Grimm M, Lauer A, Grosgen S, Thiel A, Lehmann J, Winkler J, et al.
J Nutr Biochem . 2019 Mar; 67:123-137. PMID: 30889441
A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain...