Marcus Koppitz
Overview
Explore the profile of Marcus Koppitz including associated specialties, affiliations and a list of published articles.
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8
Citations
110
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0
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Recent Articles
1.
Lucking U, Wortmann L, Wengner A, Lefranc J, Lienau P, Briem H, et al.
J Med Chem
. 2020 Jun;
63(13):7293-7325.
PMID: 32502336
The ATR kinase plays a key role in the DNA damage response by activating essential signaling pathways of DNA damage repair, especially in response to replication stress. Because DNA damage...
2.
Schulze V, Klar U, Kosemund D, Wengner A, Siemeister G, Stockigt D, et al.
J Med Chem
. 2020 Apr;
63(15):8025-8042.
PMID: 32338514
Inhibition of monopolar spindle 1 (MPS1) kinase represents a novel approach to cancer treatment: instead of arresting the cell cycle in tumor cells, cells are driven into mitosis irrespective of...
3.
Wortmann L, Lindenthal B, Muhn P, Walter A, Nubbemeyer R, Heldmann D, et al.
J Med Chem
. 2019 Nov;
62(22):10321-10341.
PMID: 31670515
The human luteinizing hormone receptor (hLH-R) is a member of the glycoprotein hormone family of G-protein-coupled receptors (GPCRs), activated by luteinizing hormone (hLH) and essentially involved in the regulation of...
4.
Koppitz M, Brauer N, Ter Laak A, Irlbacher H, Rotgeri A, Coelho A, et al.
Bioorg Med Chem Lett
. 2019 Aug;
29(18):2700-2705.
PMID: 31362919
Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES produces, as part of the prostaglandin pathway, prostaglandin E2 which is a well-known...
5.
Wengner A, Siemeister G, Koppitz M, Schulze V, Kosemund D, Klar U, et al.
Mol Cancer Ther
. 2016 Feb;
15(4):583-92.
PMID: 26832791
Monopolar spindle 1 (Mps1) has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells. Here,...
6.
Koppitz M
J Comb Chem
. 2008 May;
10(4):573-9.
PMID: 18510367
Efficiency is one of the most important criteria in departments responsible for the production of compounds in a library format. Consequently, this was a key factor in the initial design...
7.
Koppitz M, Eis K
Drug Discov Today
. 2006 May;
11(11-12):561-8.
PMID: 16713909
With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial...
8.
Koppitz M, Brailsford A, Wenz M
J Comb Chem
. 2005 Sep;
7(5):714-20.
PMID: 16153066
Here, we describe a system for LC/MS-based analysis and purification of compounds aiming at the minimization of manual interference in the overall process. Key elements of the concept are automated...