Marcos Fernandez-Alfara
Overview
Explore the profile of Marcos Fernandez-Alfara including associated specialties, affiliations and a list of published articles.
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8
Citations
61
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Recent Articles
1.
Garcia-Cabau C, Bartomeu A, Tesei G, Cheung K, Pose-Utrilla J, Pico S, et al.
Nature
. 2024 Dec;
637(8045):496-503.
PMID: 39633052
The inclusion of microexons by alternative splicing occurs frequently in neuronal proteins. The roles of these sequences are largely unknown, and changes in their degree of inclusion are associated with...
2.
Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress
Fernandez-Alfara M, Sibilio A, Martin J, Tusquets Uxo E, Malumbres M, Alcalde V, et al.
EMBO J
. 2023 Mar;
42(9):e111494.
PMID: 36919984
Tumor growth is influenced by a complex network of interactions between multiple cell types in the tumor microenvironment (TME). These constrained conditions trigger the endoplasmic reticulum (ER) stress response, which...
3.
Melendez E, Chondronasiou D, Mosteiro L, Martinez de Villarreal J, Fernandez-Alfara M, Lynch C, et al.
Development
. 2022 Apr;
149(8).
PMID: 35420133
The ectopic expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in...
4.
Sibilio A, Suner C, Fernandez-Alfara M, Martin J, Berenguer A, Calon A, et al.
iScience
. 2022 Mar;
25(2):103790.
PMID: 35243213
Upon tissue injury, cytokine expression reprogramming transiently remodels the inflammatory immune microenvironment to activate repair processes and subsequently return to homeostasis. However, chronic inflammation induces permanent changes in cytokine production...
5.
Pell N, Garcia-Pras E, Gallego J, Naranjo-Suarez S, Balvey A, Suner C, et al.
Mol Metab
. 2021 Nov;
54:101388.
PMID: 34774811
Objective: Obesity represents a growing health problem that is reaching pandemic dimensions and lacks effective cures, thus highlighting an urgent need for better mechanistic understanding and new therapeutic strategies. Unlike...
6.
Goldstein J, Sengul H, Messemer K, Fernandez-Alfara M, Garbern J, Kristl A, et al.
Blood
. 2019 Sep;
134(20):1712-1716.
PMID: 31530563
Tightly regulated production of mature blood cells is essential for health and survival in vertebrates and dependent on discrete populations of blood-forming (hematopoietic) stem and progenitor cells. Prior studies suggested...
7.
Gutierrez-Vazquez C, Rodriguez-Galan A, Fernandez-Alfara M, Mittelbrunn M, Sanchez-Cabo F, Martinez-Herrera D, et al.
Sci Rep
. 2017 Jun;
7(1):3508.
PMID: 28615644
microRNAs (miRNAs) are tightly regulated during T lymphocyte activation to enable the establishment of precise immune responses. Here, we analyzed the changes of the miRNA profiles of T cells in...
8.
Gutierrez-Erlandsson S, Herrero-Vidal P, Fernandez-Alfara M, Hernandez-Garcia S, Gonzalo-Flores S, Mudarra-Rubio A, et al.
Mol Cancer
. 2013 Oct;
12(1):127.
PMID: 24148564
Malignant tumors of the central nervous system (CNS) are the 10th most frequent cause of cancer mortality. Despite the strong malignancy of some such tumors, oncogenic mutations are rarely found...