Marcelo Falchetti
Overview
Explore the profile of Marcelo Falchetti including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
16
Citations
119
Followers
0
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Recent Articles
1.
Jing R, Scarfo I, Najia M, Lummertz da Rocha E, Han A, Sanborn M, et al.
Cell Stem Cell
. 2025 Mar;
PMID: 40088890
No abstract available.
2.
Jing R, Falchetti M, Han T, Najia M, Hensch L, Meader E, et al.
Cell Stem Cell
. 2025 Jan;
32(2):326-328.
PMID: 39818202
No abstract available.
3.
Li H, Cote P, Kuoch M, Ezike J, Frenis K, Afanassiev A, et al.
Nat Methods
. 2024 Dec;
22(2):422-434.
PMID: 39639169
Over a lifetime, hematopoietic stem cells (HSCs) adjust their lineage output to support age-aligned physiology. In model organisms, stereotypic waves of hematopoiesis have been observed corresponding to defined age-biased HSC...
4.
Jing R, Falchetti M, Han T, Najia M, Hensch L, Meader E, et al.
Cell Stem Cell
. 2024 Nov;
32(1):71-85.e5.
PMID: 39504968
Elucidating mechanisms of T cell development can guide in vitro T cell differentiation from induced pluripotent stem cells (iPSCs) and facilitate off-the-shelf T cell-based immunotherapies. Using a stroma-free human iPSC-T...
5.
Li Z, Fierstein S, Tanaka-Yano M, Frenis K, Chen C, Wang D, et al.
Leukemia
. 2024 Oct;
39(1):87-97.
PMID: 39354203
Acute myeloid leukemia (AML) shows variable clinical outcome. The normal hematopoietic cell of origin impacts the clinical behavior of AML, with AML from hematopoietic stem cells (HSCs) prone to chemotherapy...
6.
Guimaraes G, Maklouf G, Teixeira C, de Oliveira Santos L, Tessarollo N, de Toledo N, et al.
Nat Commun
. 2024 Jul;
15(1):5694.
PMID: 38972873
Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity and tumorigenic behaviors. Here, we integrate single-cell RNA-sequencing data from different cancer types, identifying...
7.
Schulz D, Feulner L, Santos Rubenich D, Heimer S, Rohrmuller S, Reinders Y, et al.
Mol Oncol
. 2023 Dec;
18(2):431-452.
PMID: 38103190
The programmed cell death 1 ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) axis is primarily associated with immunosuppression in cytotoxic T lymphocytes (CTLs). However, mounting evidence is supporting the...
8.
Falchetti M, Delgobo M, Zancanaro H, Almeida K, das Neves R, Dos Santos B, et al.
Comput Biol Med
. 2022 Dec;
152:106347.
PMID: 36493734
Auranofin is a thioredoxin reductase-1 inhibitor originally approved for the treatment of rheumatoid arthritis. Recently, auranofin has been repurposed as an anticancer drug, with pharmacological activity reported in multiple cancer...
9.
Rocha B, Picoli C, Goncalves B, Silva W, Costa A, Moraes M, et al.
Angiogenesis
. 2022 Oct;
26(1):129-166.
PMID: 36183032
Cancer cells are embedded within the tissue and interact dynamically with its components during cancer progression. Understanding the contribution of cellular components within the tumor microenvironment is crucial for the...
10.
Jing R, Scarfo I, Najia M, Lummertz da Rocha E, Han A, Sanborn M, et al.
Cell Stem Cell
. 2022 Aug;
29(8):1181-1196.e6.
PMID: 35931029
Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited resource for cell therapies, but the derivation of mature cell types remains challenging. The histone methyltransferase EZH1 is a negative...