Marcello Casertano
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Explore the profile of Marcello Casertano including associated specialties, affiliations and a list of published articles.
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21
Citations
139
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Recent Articles
1.
Spacho N, Casertano M, Imperatore C, Papadopoulos C, Menna M, Eleftheriadis N
Chemistry
. 2024 Jul;
30(53):e202402279.
PMID: 39041705
Human 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that possesses an important role in (neuro)inflammatory diseases. The pocket of the enzyme plays the role of a chiral catalyst, and therefore chirality...
2.
Agognon A, Casertano M, Vito A, Orso S, Cabaro S, Mormone F, et al.
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38892230
Marine natural products constitute a great source of potential new antidiabetic drugs. The aim of this study was to evaluate the role of phosphoeleganin (PE), a polyketide purified from the...
3.
Sparaco R, Cinque P, Scognamiglio A, Corvino A, Caliendo G, Fiorino F, et al.
Molecules
. 2024 Apr;
29(7).
PMID: 38611877
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium...
4.
Casertano M, Esposito E, Bello I, Indolfi C, Putra M, Di Cesare Mannelli L, et al.
Mar Drugs
. 2023 Dec;
21(12).
PMID: 38132963
Hydrogen sulfide (HS) is a signaling molecule endogenously produced within mammals' cells that plays an important role in inflammation, exerting anti-inflammatory effects. In this view, the research has shown a...
5.
Casertano M, Vito A, Aiello A, Imperatore C, Menna M
Pharmaceutics
. 2023 Sep;
15(9).
PMID: 37765290
Background: Type 2 diabetes mellitus (T2DM) is an ongoing, risky, and costly health problem that therefore always requires new treatment options. Moreover, although several drugs are available, only 36% of...
6.
Casertano M, Genovese M, Santi A, Pranzini E, Balestri F, Piazza L, et al.
Pharmaceutics
. 2023 Feb;
15(2).
PMID: 36839851
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by...
7.
Sparaco R, Scognamiglio A, Corvino A, Caliendo G, Fiorino F, Magli E, et al.
Molecules
. 2023 Jan;
28(1).
PMID: 36615252
We recently identified 6-nitrodopamine and other nitro-catecholamines (6-nitrodopa, 6-nitroadrenaline), indicating that the endothelium has the ability to nitrate the classical catecholamines (dopamine, noradrenaline, and adrenaline). In order to investigate whether...
8.
Sparaco R, Kedzierska E, Kaczor A, Bielenica A, Magli E, Severino B, et al.
Molecules
. 2022 Oct;
27(19).
PMID: 36235029
A new series of 5-norbornene-2-carboxamide derivatives was prepared and their affinities to the 5-HT, 5-HT, and 5-HT receptors were evaluated and compared to a previously synthesized series of derivatives characterized...
9.
Casertano M, Genovese M, Piazza L, Balestri F, Del Corso A, Vito A, et al.
Pharmaceuticals (Basel)
. 2022 Mar;
15(3).
PMID: 35337123
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorders with acute and long-term serious complications. The onset of DM, with over 90% of cases of diabetes...
10.
Casertano M, Genovese M, Paoli P, Santi A, Aiello A, Menna M, et al.
Mar Drugs
. 2022 Jan;
20(1).
PMID: 35049920
The chemical investigation of the Mediterranean ascidian has led to the isolation of a new lepadin, named lepadin L, and two known metabolites belonging to the same family, lepadins A...