Marcel Klein
Overview
Explore the profile of Marcel Klein including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
18
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Recent Articles
1.
Klein M, Failla A, Hermey G
J Biol Chem
. 2023 Sep;
299(10):105216.
PMID: 37660918
The Vps10p-domain (Vps10p-D) receptor family consists of Sortilin, SorLA, SorCS1, SorCS2, and SorCS3. They mediate internalization and intracellular sorting of specific cargo in various cell types, but underlying molecular determinants...
2.
Klein M, Hermey G
Neural Regen Res
. 2022 Dec;
18(7):1463-1471.
PMID: 36571343
Evidence from genetics and from analyzing cellular and animal models have converged to suggest links between neurodegenerative disorders of early and late life. Here, we summarize emerging links between the...
3.
Binkle L, Klein M, Borgmeyer U, Kuhl D, Hermey G
Mol Brain
. 2022 Feb;
15(1):18.
PMID: 35183222
SorLA is a member of the Vps10p-domain (Vps10p-D) receptor family of type-I transmembrane proteins conveying neuronal endosomal sorting. The extracellular/luminal moiety of SorLA has a unique mosaic domain composition and...
4.
Klein M, Kaleem A, Oetjen S, Wunkhaus D, Binkle L, Schilling S, et al.
Autophagy
. 2021 Dec;
18(9):2068-2085.
PMID: 34964690
PSENEN/PEN2 is the smallest subunit of the γ-secretase complex, an intramembrane protease that cleaves proteins within their transmembrane domains. Mutations in components of the γ-secretase underlie familial Alzheimer disease. In...
5.
Klein M, Lohr C, Droste D
Front Aging Neurosci
. 2020 Jun;
12:172.
PMID: 32581775
Astrocytes have a high impact on the structure of the central nervous system, as they control neural activity, development, and plasticity. Heterogeneity of astrocytes has been shown before, but so...