Marc Roy
Overview
Explore the profile of Marc Roy including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
103
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Recent Articles
1.
Geles K, Gao Y, Giannakou A, Sridharan L, Yamin T, Zhang J, et al.
Cell Rep Med
. 2021 Jun;
2(5):100279.
PMID: 34095881
Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation...
2.
Howe W, Brooks J, Tierney P, Pang J, Rossi A, Young D, et al.
Brain Struct Funct
. 2018 Jan;
223(2):1035-1047.
PMID: 29299690
A loss-of-function polymorphism in the α5 nicotinic acetylcholine receptor (nAChR) subunit gene has been linked to both drug abuse and schizophrenia. The α5 nAChR subunit is strategically positioned in the...
3.
Cook J, Obert L, Koza-Taylor P, Coskran T, Opsahl A, Ziemek D, et al.
Toxicol Sci
. 2017 Oct;
161(1):58-75.
PMID: 28973697
Pharmaceuticals and chemicals produce hemangiosarcomas (HS) in mice, often by nongenotoxic, proliferative mechanisms. A mode-of-action (MOA) for hemangiosarcoma was proposed based on information presented at an international workshop (Cohen et...
4.
Pirie-Shepherd S, Painter C, Whalen P, Vizcarra P, Roy M, Qian J, et al.
PLoS One
. 2017 Jul;
12(7):e0179561.
PMID: 28727782
The fetal oncogene 5T4 is a cell surface protein, with overexpression observed in a variety of cancers as compared to normal adult tissue. The ability to select patients with tumors...
5.
Kamperschroer C, ODonnell L, Schneider P, Li D, Roy M, Coskran T, et al.
J Immunotoxicol
. 2013 Mar;
11(1):35-43.
PMID: 23461640
A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that...
6.
Stanton R, Sciabola S, Salatto C, Weng Y, Moshinsky D, Little J, et al.
Nucleic Acid Ther
. 2012 Aug;
22(5):344-59.
PMID: 22852836
A series of insertion patterns for chemically modified nucleotides [2'-O-methyl (2'-OMe), 2'-fluoro (2'-F), methoxyethyl (MOE), locked nucleic acid (LNA), and G-Clamp] within antisense gapmers is studied in vitro and in...
7.
Criswell K, Cook J, Morse D, Lawton M, Somps C, Obert L, et al.
Toxicol Sci
. 2012 Apr;
128(1):42-56.
PMID: 22539613
The preceding article identified key components of pregabalin's mode of action on nongenotoxic hemangiosarcoma formation in mice, including increased serum bicarbonate leading to decreased respiratory rate, increased blood pH, increased...
8.
Quantum mazes: luminescent labyrinthine semiconductor nanocrystals having a narrow emission spectrum
Lacerda S, Douglas J, Hudson S, Roy M, Johnson J, Becker M, et al.
ACS Nano
. 2009 Feb;
1(4):337-47.
PMID: 19206685
We exploit the polytypism of group II-VI semiconductors and the long-range dipolar interactions typical of CdSe nanoparticle formation to modulate the geometrical structure and the optical emission properties of novel...
9.
Roy M, Leclerc D, Wu Q, Gupta S, Kruger W, Rozen R
J Cell Biochem
. 2008 Jul;
105(2):467-76.
PMID: 18615588
Valproate (VPA) treatment in pregnancy leads to congenital anomalies, possibly by disrupting folate or homocysteine metabolism. Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism,...