Marc Pesant
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Explore the profile of Marc Pesant including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
152
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Recent Articles
1.
Spino C, Pesant M, Dory Y
Angew Chem Int Ed Engl
. 2018 May;
37(23):3262-3265.
PMID: 29711428
The chronology of π-orbital mixing in the Diels-Alder cycloaddition of butadiene and ethylene differs for the two main interactions, the HOMO -LUMO and HOMO -LUMO interactions. The C2-C3 π bond...
2.
Hesp C, MacDonald M, Zahedi M, Bilodeau D, Zhao S, Pesant M, et al.
Org Lett
. 2015 Sep;
17(20):5136-9.
PMID: 26417922
Catalysts possessing sufficient activity to achieve intermolecular alkene hydroaminations under mild conditions are rare, and this likely accounts for the scarcity of asymmetric variants of this reaction. Herein, highly diastereoselective...
3.
Fader L, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, et al.
ACS Med Chem Lett
. 2014 Jun;
5(4):422-7.
PMID: 24900852
An assay recapitulating the 3' processing activity of HIV-1 integrase (IN) was used to screen the Boehringer Ingelheim compound collection. Hit-to-lead and lead optimization beginning with compound 1 established the...
4.
Hucke O, Coulombe R, Bonneau P, Bertrand-Laperle M, Brochu C, Gillard J, et al.
J Med Chem
. 2013 Jun;
57(5):1932-43.
PMID: 23773186
The design and preliminary SAR of a new series of 1H-quinazolin-4-one (QAZ) allosteric HCV NS5B thumb pocket 2 (TP-2) inhibitors was recently reported. To support optimization efforts, a molecular dynamics...
5.
Decor A, Grand-Maitre C, Hucke O, OMeara J, Kuhn C, Constantineau-Forget L, et al.
Bioorg Med Chem Lett
. 2013 Jun;
23(13):3841-7.
PMID: 23726345
We describe here the design, synthesis and biological evaluation of antiviral compounds acting against human rhinovirus (HRV). A series of aminothiazoles demonstrated pan-activity against the HRV genotypes screened and productive...
6.
MacDonald M, Hesp C, Schipper D, Pesant M, Beauchemin A
Chemistry
. 2013 Jan;
19(8):2597-601.
PMID: 23307591
No abstract available.
7.
Liu J, Towle M, Cheng H, Saxton P, Reardon C, Wu J, et al.
Anticancer Res
. 2007 Jun;
27(3B):1509-18.
PMID: 17595769
Laulimalide is a cytotoxic natural product isolated from marine sponges. It is structurally distinct from taxanes. However, like paclitaxel, laulimalide binds to tubulin and enhances microtubule assembly and stabilization. It...
8.
Gallagher Jr B, Fang F, Johannes C, Pesant M, Tremblay M, Zhao H, et al.
Bioorg Med Chem Lett
. 2004 Jan;
14(3):575-9.
PMID: 14741246
Analogues of the marine natural product (-)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.