Marc Lake
Overview
Explore the profile of Marc Lake including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
224
Followers
0
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Recent Articles
1.
Chan S, Belmar N, Ho S, Rogers B, Stickler M, Graham M, et al.
Nat Cancer
. 2022 Mar;
3(3):337-354.
PMID: 35256819
Costimulatory receptors such as glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) play key roles in regulating the effector functions of T cells. In human clinical trials, however, GITR agonist antibodies...
2.
Ye S, Cohen D, Belmar N, Choi D, Tan S, Sho M, et al.
Cancer Immunol Res
. 2019 Aug;
7(11):1864-1875.
PMID: 31462409
Agonistic CD40 monoclonal antibodies (mAb) have demonstrated some clinical activity, but with dose-limiting toxicity. To reduce systemic toxicity, we developed a bispecific molecule that was maximally active in the presence...
3.
Guo J, Xiao Y, Iyer R, Lu X, Lake M, Ladror U, et al.
PLoS One
. 2019 Aug;
14(8):e0219829.
PMID: 31393905
Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with...
4.
Argiriadi M, Benatuil L, Dubrovska I, Egan D, Gao L, Greischar A, et al.
BMC Mol Cell Biol
. 2019 Aug;
20(1):29.
PMID: 31382872
Background: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L...
5.
Petros A, Korepanova A, Jakob C, Qiu W, Panchal S, Wang J, et al.
J Med Chem
. 2019 Apr;
62(8):4120-4130.
PMID: 30933499
Apolipoprotein E is a 299-residue lipid carrier protein produced in both the liver and the brain. The protein has three major isoforms denoted apoE2, apoE3, and apoE4 which differ at...
6.
Korepanova A, Longenecker K, Pratt S, Panchal S, Clark R, Lake M, et al.
Bioorg Med Chem Lett
. 2017 Dec;
28(3):437-440.
PMID: 29287958
NAMPT expression is elevated in many cancers, making this protein a potential target for anticancer therapy. We have carried out both NMR based and TR-FRET based fragment screens against human...
7.
Stockmann H, Todorovic V, Richardson P, Marin V, Scott V, Gerstein C, et al.
J Am Chem Soc
. 2017 Oct;
139(46):16822-16829.
PMID: 29068676
Ligand-binding assays are the linchpin of drug discovery and medicinal chemistry. Cell-surface receptors and their ligands have traditionally been characterized by radioligand-binding assays, which have low temporal and spatial resolution...
8.
Chen J, Kang D, Xu J, Lake M, Hogan J, Sun C, et al.
Nat Commun
. 2013 Sep;
4:2501.
PMID: 24071625
TRPA1 is an ion channel and has been proposed as a thermosensor across species. In invertebrate and ancestral vertebrates such as fly, mosquito, frog, lizard and snakes, TRPA1 serves as...