Marc Gauthier
Overview
Explore the profile of Marc Gauthier including associated specialties, affiliations and a list of published articles.
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10
Citations
314
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Recent Articles
1.
Gauthier M, Kale S, Ray A
Immunol Rev
. 2025 Feb;
330(1):e70011.
PMID: 39991821
Asthma is orchestrated by an aberrant immune response involving a complex interplay between multiple inflammatory cell types. An increase in Th2 cells in the asthmatic airway is a hallmark of...
2.
Fahy J, Jackson N, Sajuthi S, Pruesse E, Moore C, Everman J, et al.
Am J Respir Crit Care Med
. 2024 Nov;
211(2):194-204.
PMID: 39601762
Corticosteroid-responsive type 2 (T2) inflammation underlies the T2-high asthma endotype. However, we hypothesized that type 1 (T1) inflammation, possibly related to viral infection, may also influence corticosteroid response. To determine...
3.
Gauthier M, Kale S, Oriss T, Gorry M, Ramonell R, Dalton K, et al.
J Allergy Clin Immunol
. 2023 Mar;
152(1):94-106.e12.
PMID: 36893862
Background: Type 1 (T1) inflammation (marked by IFN-γ expression) is now consistently identified in subsets of asthma cohorts, but how it contributes to disease remains unclear. Objective: We sought to...
4.
Gauthier M, Kale S, Oriss T, Scholl K, Das S, Yuan H, et al.
J Allergy Clin Immunol
. 2021 Jun;
149(1):113-124.e7.
PMID: 34146578
Background: Many patients with severe asthma (SA) fail to respond to type 2 inflammation-targeted therapies. We previously identified a cohort of subjects with SA expressing type 1 inflammation manifesting with...
5.
Camiolo M, Kale S, Oriss T, Gauthier M, Ray A
Curr Opin Immunol
. 2021 Mar;
72:34-42.
PMID: 33773471
Asthma as a clinical entity manifests with a broad spectrum of disease severity. Unlike milder asthma, severe disease is poorly controlled by inhaled corticosteroids, the current standard of care. Transcriptomic...
6.
Camiolo M, Gauthier M, Kaminski N, Ray A, Wenzel S
J Allergy Clin Immunol
. 2020 Jun;
146(2):315-324.e7.
PMID: 32531372
Background: More than 300 million people carry a diagnosis of asthma, with data to suggest that they are at a higher risk for infection or adverse outcomes from severe acute...
7.
Ray A, Camiolo M, Fitzpatrick A, Gauthier M, Wenzel S
Physiol Rev
. 2020 Jan;
100(3):983-1017.
PMID: 31917651
While the term has long been known to describe heterogeneous groupings of patients, only recently have data evolved which enable a molecular understanding of the clinical differences. The evolution of...
8.
9.
Gauthier M, Chakraborty K, Oriss T, Raundhal M, Das S, Chen J, et al.
JCI Insight
. 2017 Jul;
2(13).
PMID: 28679952
We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated in 50% of patients with severe asthma, despite high dose corticosteroid (CS)...
10.
Gauthier M, Ray A, Wenzel S
Am J Respir Crit Care Med
. 2015 Jul;
192(6):660-8.
PMID: 26161792
Our understanding of asthma has evolved over time from a singular disease to a complex of various phenotypes, with varied natural histories, physiologies, and responses to treatment. Early therapies treated...