Marc Bracke
Overview
Explore the profile of Marc Bracke including associated specialties, affiliations and a list of published articles.
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Articles
128
Citations
4267
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Recent Articles
1.
Depetter Y, Geurs S, De Vreese R, Goethals S, Vandoorn E, Laevens A, et al.
Int J Cancer
. 2019 Jan;
145(3):735-747.
PMID: 30694564
Our study investigates the biochemical and functional impact of selective histone deacetylase 6 (HDAC6) inhibitors, a promising class of novel therapeutics, in several cancer models. Selective HDAC6 inhibitors (Tubathian A,...
2.
De Jaeghere E, De Vlieghere E, Van Hoorick J, Van Vlierberghe S, Wagemans G, Pieters L, et al.
Biomaterials
. 2018 Jan;
158:95-105.
PMID: 29306747
Peritoneal metastasis is a major cause of death and preclinical models are urgently needed to enhance therapeutic progress. This study reports on a hybrid hydrogel-polylactic acid (PLA) scaffold that mimics...
3.
Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, et al.
Cancer Res
. 2017 Dec;
78(3):659-670.
PMID: 29217764
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAFs are abundantly present, the effects of...
4.
Drebert Z, De Vlieghere E, Bridelance J, de Wever O, De Bosscher K, Bracke M, et al.
Exp Cell Res
. 2017 Dec;
362(2):332-342.
PMID: 29196164
Cancer-associated fibroblasts (CAFs) support cancer growth, invasion, and metastasis. Glucocorticoids (GCs), drugs often administered together with chemotherapy, are steroidal ligands of the glucocorticoid receptor (GR), a transcription factor which upon...
5.
Lapeire L, Hendrix A, Lecoutere E, Van Bockstal M, Vandesompele J, Maynard D, et al.
Oncotarget
. 2017 May;
8(29):47239-47249.
PMID: 28525384
Adipose tissue secretes a plethora of adipokines as evidenced by characterization of subcutaneous and visceral adipose tissue secretomes. However, adipose tissue composition and secretion pattern is depot and disease dependent,...
6.
Verset L, Tommelein J, Decaestecker C, De Vlieghere E, Bracke M, Salmon I, et al.
Tumour Biol
. 2017 Mar;
39(3):1010428317695024.
PMID: 28349819
FHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation,...
7.
Bridelance J, Drebert Z, de Wever O, Bracke M, Beck I
Curr Drug Targets
. 2016 Nov;
18(8):964-982.
PMID: 27804849
Historically, the word cancer is derived from the Latin cancer, as the red swollen arteries near a tumor reminded the physician Galenus and his fellow Romans of a red crab....
8.
Drebert Z, MacAskill M, Doughty-Shenton D, De Bosscher K, Bracke M, Hadoke P, et al.
Vascul Pharmacol
. 2016 Oct;
89:19-30.
PMID: 27717848
Angiogenesis is important in cancer progression and can be influenced by tumor-associated myofibroblasts. We addressed the hypothesis that glucocorticoids indirectly affect angiogenesis by altering the release of pro-angiogenic factors from...
9.
Sundahl N, Clarisse D, Bracke M, Offner F, Vanden Berghe W, Beck I
Oncoscience
. 2016 Oct;
3(7-8):188-202.
PMID: 27713909
Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of...
10.
Tommelein J, Gremonprez F, Verset L, De Vlieghere E, Wagemans G, Gespach C, et al.
Oncotarget
. 2016 Oct;
7(46):75603-75615.
PMID: 27689329
In patients with rectal prolapse is the prevalence of colorectal cancer increased, suggesting that a colorectal tumor may induce rectal prolapse. Establishment of tumor xenografts in immunodeficient mice after orthotopic...