Marc B Brown
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Explore the profile of Marc B Brown including associated specialties, affiliations and a list of published articles.
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70
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895
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Recent Articles
11.
Shafaie S, Hutter V, Brown M, Cook M, Chau D
PLoS One
. 2017 Oct;
12(10):e0186799.
PMID: 29084285
In vitro cell based models have been invaluable tools for studying cell behaviour and for investigating drug disposition, toxicity and potential adverse effects of administered drugs. Within this drug discovery...
12.
Lenn J, Neil J, Donahue C, Demock K, Tibbetts C, Cote-Sierra J, et al.
J Invest Dermatol
. 2017 Sep;
138(2):282-290.
PMID: 28942363
It is generally recognized that only relatively small molecular weight (typically < ∼ 500 Da) drugs can effectively permeate through intact stratum corneum. Here, we challenge this orthodoxy using a...
13.
Shetage S, Traynor M, Brown M, Galliford T, Chilcott R
Sci Rep
. 2017 Aug;
7(1):8999.
PMID: 28827705
Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate...
14.
Patel A, Keir S, Brown M, Hider R, Jones S, Page C
Mol Pharm
. 2016 Aug;
13(10):3439-3448.
PMID: 27568865
There is a paucity of data describing the impact of salt counterions on the biological performance of inhaled medicines in vivo. The aim of this study was to determine if...
15.
Shafaie S, Hutter V, Cook M, Brown M, Chau D
Biores Open Access
. 2016 May;
5(1):94-108.
PMID: 27158563
Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development...
16.
Turner R, Weaver S, Caserta F, Brown M
Int J Pharm Compd
. 2016 Apr;
20(1):71-80.
PMID: 27125057
The aim of this study was to use in vitro nail models to investigate the potential of a novel base formulation (Recura) containing either fluconazole or miconazole for the treatment...
17.
Fiala S, Roman M, Inacio R, Mashal S, Brown M, Jones S
Int J Pharm
. 2016 Jan;
499(1-2):403-411.
PMID: 26732522
The manner in which the eutectic cream EMLA enhances the percutaneous penetration of lidocaine and prilocaine into human skin is still not fully understood. The purpose of this study was...
18.
Shetage S, Traynor M, Brown M, Raji M, Graham-Kalio D, Chilcott R
Skin Res Technol
. 2013 Jul;
20(1):97-107.
PMID: 23865719
Background/purpose: The superficial layer on the skin surface, known as the acid mantle, comprises a mixture of sebum, sweat, corneocyte debris and constituents of natural moisturizing factor. Thus, the phrase...
19.
Reid M, Benaouda F, Khengar R, Jones S, Brown M
Int J Pharm
. 2013 May;
452(1-2):157-65.
PMID: 23684656
Drug loaded hydrofluoroalkane (HFA) sprays can generate effective pharmaceutical formulations, but a deeper understanding of the manner in which these dynamic systems drive the process of in situ semi-solid dosage...
20.
Ali J, Camilleri P, Brown M, Hutt A, Kirton S
J Chem Inf Model
. 2012 Nov;
52(11):2950-7.
PMID: 23121381
Recently the authors published a robust QSPR model of aqueous solubility which exploited the computationally derived molecular descriptor topographical polar surface area (TPSA) alongside experimentally determined melting point and logP....