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Marc-Andre Laplante

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Articles 15
Citations 221
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Recent Articles
1.
Le Quang K, Bouchareb R, Lachance D, Laplante M, El Husseini D, Boulanger M, et al.
Arterioscler Thromb Vasc Biol . 2014 Sep; 34(10):2283-91. PMID: 25231636
Objective: This study aimed to determine the potential impact of type 2 diabetes mellitus on left ventricular dysfunction and the development of calcified aortic valve disease using a dyslipidemic mouse...
2.
Avramoglu R, Laplante M, Le Quang K, Deshaies Y, Despres J, Larose E, et al.
Can J Diabetes . 2014 Feb; 37(5):351-8. PMID: 24500564
Cardiovascular complications (CVC) are the most common causes of death in patients with type 2 diabetes (T2D). However the pathophysiological determinants and molecular mechanisms involved in the progression of CVC...
3.
Jenkins Y, Sun T, Markovtsov V, Foretz M, Li W, Nguyen H, et al.
PLoS One . 2013 Dec; 8(12):e81870. PMID: 24339975
Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of...
4.
Laplante M, Charbonneau A, Avramoglu R, Pelletier P, Fang X, Bachelard H, et al.
Am J Physiol Endocrinol Metab . 2013 Jul; 305(5):E573-84. PMID: 23820620
Cholesterol and triglyceride-rich Western diets are typically associated with an increased occurrence of type 2 diabetes and vascular diseases. This study aimed to assess the relative impact of dietary cholesterol...
5.
Wu R, Duchemin S, Laplante M, de Champlain J, Girouard H
Am J Hypertens . 2011 Aug; 24(11):1239-44. PMID: 21833043
Background: Inflammation and oxidative stress have been identified as integral parts in the pathogenesis of hypertension. Cyclo-oxygenase-2 which could elicit inflammation and free radicals generation appears to be a key...
6.
Laplante M, Monassier L, Freund M, Bousquet P, Gachet C
Endocrinology . 2010 Feb; 151(5):2060-70. PMID: 20185765
Extracellular nucleotides have been shown to trigger intracellular calcium release and influence leptin secretion in differentiated white and brown adipocytes through activation of various but not clearly identified P2 receptors....
7.
Monassier L, Laplante M, Jaffre F, Bousquet P, Maroteaux L, de Champlain J
Hypertension . 2008 Jul; 52(2):301-7. PMID: 18591460
We established previously that 5-HT(2B) receptors are involved in cardiac hypertrophy through the regulation of hypertrophic cytokines in cardiac fibroblasts. Moreover, the generation of reactive oxygen species and tumor necrosis...
8.
Laplante M, de Champlain J
Can J Physiol Pharmacol . 2006 Jul; 84(1):21-8. PMID: 16845887
The NAD(P)H oxidase is an enzyme assembled at the cellular membrane able to produce superoxide anion from NADH or NAD(P)H (nicotinamide adenine dinucleotide phosphate). It is one of the main...
9.
Wu R, Laplante M, de Champlain J
Med Sci (Paris) . 2006 Jan; 22(1):20-2. PMID: 16386213
No abstract available.
10.
Wu R, Laplante M, de Champlain J
Hypertension . 2005 Apr; 45(6):1139-44. PMID: 15851630
Angiotensin II is an important oxidative stress mediator. Our previous studies have indicated that the potent antioxidative properties of acetylsalicylic acid play an important role in its cardiovascular protective effects....