Manu Shubhdarshan Shukla
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Explore the profile of Manu Shubhdarshan Shukla including associated specialties, affiliations and a list of published articles.
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9
Citations
343
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Recent Articles
1.
Shukla M, Hussain Syed S, Boopathi R, Simon E, Nahata S, Ramos L, et al.
Sci Rep
. 2019 Oct;
9(1):14212.
PMID: 31578361
Chromatin remodelers are complexes able to both alter histone-DNA interactions and to mobilize nucleosomes. The mechanism of their action and the conformation of remodeled nucleosomes remain a matter of debates....
2.
Charles Richard J, Shukla M, Menoni H, Ouararhni K, Nisar Lone I, Roulland Y, et al.
PLoS Genet
. 2016 Jul;
12(7):e1006221.
PMID: 27467129
FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair. Here, we present evidence that FACT could...
3.
Nisar Lone I, Shukla M, Charles Richard J, Peshev Z, Dimitrov S, Angelov D
PLoS Genet
. 2013 Oct;
9(9):e1003830.
PMID: 24086160
NF-κB is a key transcription factor regulating the expression of inflammatory responsive genes. How NF-κB binds to naked DNA templates is well documented, but how it interacts with chromatin is...
4.
Menoni H, Shukla M, Gerson V, Dimitrov S, Angelov D
Nucleic Acids Res
. 2011 Sep;
40(2):692-700.
PMID: 21930508
In this work we have studied the effect of chromatin structure on the base excision repair (BER) efficiency of 8-oxoG. As a model system we have used precisely positioned dinucleosomes...
5.
Meyer S, Becker N, Hussain Syed S, Goutte-Gattat D, Shukla M, Hayes J, et al.
Nucleic Acids Res
. 2011 Aug;
39(21):9139-54.
PMID: 21835779
The interaction of histone H1 with linker DNA results in the formation of the nucleosomal stem structure, with considerable influence on chromatin organization. In a recent paper [Syed,S.H., Goutte-Gattat,D., Becker,N.,...
6.
Shukla M, Hussain Syed S, Goutte-Gattat D, Charles Richard J, Montel F, Hamiche A, et al.
Nucleic Acids Res
. 2010 Dec;
39(7):2559-70.
PMID: 21131284
Histone variants within the H2A family show high divergences in their C-terminal regions. In this work, we have studied how these divergences and in particular, how a part of the...
7.
Hussain Syed S, Goutte-Gattat D, Becker N, Meyer S, Shukla M, Hayes J, et al.
Proc Natl Acad Sci U S A
. 2010 May;
107(21):9620-5.
PMID: 20457934
Despite the key role of the linker histone H1 in chromatin structure and dynamics, its location and interactions with nucleosomal DNA have not been elucidated. In this work we have...
8.
Shukla M, Hussain Syed S, Montel F, Faivre-Moskalenko C, Bednar J, Travers A, et al.
Proc Natl Acad Sci U S A
. 2010 Jan;
107(5):1936-41.
PMID: 20080697
Chromatin remodelers are sophisticated nano-machines that are able to alter histone-DNA interactions and to mobilize nucleosomes. Neither the mechanism of their action nor the conformation of the remodeled nucleosomes are,...
9.
Hussain Syed S, Boulard M, Shukla M, Gautier T, Travers A, Bednar J, et al.
Nucleic Acids Res
. 2009 Jun;
37(14):4684-95.
PMID: 19506029
In this work we have studied the properties of the novel mouse histone variant H2AL2. H2AL2 was used to reconstitute nucleosomes and the structural and functional properties of these particles...