Manon Ruffin
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Explore the profile of Manon Ruffin including associated specialties, affiliations and a list of published articles.
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28
Citations
419
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Recent Articles
1.
Mesinele J, Ruffin M, Guillot L, Boelle P, Corvol H
Sci Rep
. 2024 Nov;
14(1):27036.
PMID: 39511324
Pseudomonas aeruginosa (Pa) and Methicillin susceptible Staphylococcus aureus (MSSA) are the predominant bacteria found in the airways of people with cystic fibrosis (pwCF), significantly contributing to lung disease progression. While...
2.
Brax S, Gaudin C, Calmel C, Boelle P, Corvol H, Ruffin M, et al.
Eur J Cell Biol
. 2024 Apr;
103(2):151416.
PMID: 38636185
Airway epithelial cells form a physical barrier against inhaled pathogens and coordinate innate immune responses in the lungs. Bronchial cells in people with cystic fibrosis (pwCF) are colonized by Pseudomonas...
3.
Mesinele J, Ruffin M, Guillot L, Boelle P, Corvol H
J Cyst Fibros
. 2023 Jul;
22(5):901-908.
PMID: 37422431
Background: Pseudomonas aeruginosa (Pa) infection is detrimental to people with cystic fibrosis (pwCF). Several clinical and genetic factors predispose to early Pa infections. However, the role of earlier infections with...
4.
Renteria A, Valera F, Maniakas A, Adam D, Filali-Mouhim A, Ruffin M, et al.
Otolaryngol Head Neck Surg
. 2023 May;
169(4):1055-1063.
PMID: 37125631
Objective: Previous in vitro transcriptomic profiling suggests azithromycin exerts its effects in patients with chronic rhinosinusitis (CRS) via modulation of type 1 inflammation and restoration of epithelial barrier function. We...
5.
Bigot J, Ruffin M, Guitard J, Vellaissamy S, Thorez S, Corvol H, et al.
J Fungi (Basel)
. 2022 Dec;
8(12).
PMID: 36547601
Bronchial epithelial cells (BEC) play a crucial role in innate immunity against inhaled fungi. Indeed, in response to microorganisms, BEC synthesize proinflammatory cytokines involved in the recruitment of neutrophils. We...
6.
Mesinele J, Ruffin M, Guillot L, Corvol H
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430680
Although cystic fibrosis (CF) is recognized as a monogenic disease, due to variants within the () gene, an extreme clinical heterogeneity is described among people with CF (pwCF). Apart from...
7.
Mercier J, Calmel C, Mesinele J, Sutanto E, Merabtene F, Longchampt E, et al.
Front Mol Biosci
. 2022 Apr;
9:850261.
PMID: 35372502
Cystic fibrosis (CF), due to pathogenic variants in gene, is associated with chronic infection/inflammation responsible for airway epithelium alteration and lung function decline. Modifier genes induce phenotype variability between people...
8.
Mesinele J, Ruffin M, Guillot L, Boelle P, Corvol H, The French Cf Modifier Gene Study Investigators
J Pers Med
. 2022 Feb;
12(2).
PMID: 35207740
Lumacaftor/ivacaftor (LUMA-IVA) therapy is prescribed to people with cystic fibrosis (pwCF) homozygous for the Phe508del- variant to restore CFTR protein function. There is, however, large inter-individual variability in treatment response....
9.
Ruffin M, Bigot J, Calmel C, Mercier J, Givelet M, Oliva J, et al.
Front Immunol
. 2021 Dec;
12:714027.
PMID: 34950129
In the coronavirus disease 2019 (COVID-19) health crisis, one major challenge is to identify the susceptibility factors of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in order to adapt the recommendations for...
10.
Mesinele J, Ruffin M, Kemgang A, Guillot L, Boelle P, Corvol H
J Cyst Fibros
. 2021 Oct;
21(1):45-51.
PMID: 34629287
Background Cystic fibrosis (CF) lung disease is characterised by recurrent Pseudomonas aeruginosa (Pa) infections, leading to structural lung damage and decreased survival. The epidemiology of Pa infection and its impact...