Manon Leclerc
Overview
Explore the profile of Manon Leclerc including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
126
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0
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Recent Articles
1.
Thomas P, Leclerc M, Evitts K, Brown C, Miller W, Hanson A, et al.
Alzheimers Dement (Amst)
. 2024 May;
16(2):e12603.
PMID: 38800123
Introduction: Brain insulin resistance and deficiency is a consistent feature of Alzheimer's disease (AD). Insulin resistance can be mediated by the surface expression of the insulin receptor (IR). Cleavage of...
2.
Leclerc M, Tremblay C, Bourassa P, Schneider J, Bennett D, Calon F
J Cereb Blood Flow Metab
. 2024 Mar;
44(8):1417-1432.
PMID: 38441044
The brain is a highly demanding organ, utilizing mainly glucose but also ketone bodies as sources of energy. Glucose transporter-1 (GLUT1) and monocarboxylates transporter-1 (MCT1) respectively transport glucose and ketone...
3.
Valentin-Escalera J, Leclerc M, Calon F
J Alzheimers Dis
. 2024 Jan;
97(3):977-1005.
PMID: 38217592
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative diseases, including Alzheimer's disease (AD). To decipher the causal link behind these associations, high-fat diets (HFD)...
4.
Reveret L, Leclerc M, Emond V, Tremblay C, Loiselle A, Bourassa P, et al.
Acta Neuropathol Commun
. 2023 Nov;
11(1):173.
PMID: 37915100
No abstract available.
5.
Reveret L, Leclerc M, Emond V, Tremblay C, Loiselle A, Bourassa P, et al.
Acta Neuropathol Commun
. 2023 Oct;
11(1):159.
PMID: 37784209
Cognitive decline due to Alzheimer's disease (AD) is frequent in the geriatric population, which has been disproportionately affected by the COVID-19 pandemic. In this study, we investigated the levels of...
6.
Rhea E, Leclerc M, Yassine H, Capuano A, Tong H, Petyuk V, et al.
Aging Dis
. 2023 Aug;
15(4):1688-1725.
PMID: 37611907
Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with devastating public health consequences. While peripheral insulin resistance is a key feature of most forms of T2DM...
7.
Leclerc M, Bourassa P, Tremblay C, Caron V, Sugere C, Emond V, et al.
Brain
. 2022 Oct;
146(1):75-90.
PMID: 36280236
Central response to insulin is suspected to be defective in Alzheimer's disease. As most insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain functions must,...
8.
Biyong E, Tremblay C, Leclerc M, Caron V, Alfos S, Helbling J, et al.
Neurobiol Dis
. 2021 Nov;
161:105542.
PMID: 34737043
Background: Vitamin A (VitA), via its active metabolite retinoic acid (RA), is critical for the maintenance of memory function with advancing age. Although its role in Alzheimer's disease (AD) is...
9.
Tournissac M, Leclerc M, Valentin-Escalera J, Vandal M, Bosoi C, Planel E, et al.
Ageing Res Rev
. 2021 Sep;
72:101462.
PMID: 34534683
Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated with central and peripheral metabolic anomalies, such as impaired glucose utilization and insulin resistance. These observations led to a considerable...
10.
Leclerc M, Dudonne S, Calon F
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33805947
The scope of evidence on the neuroprotective impact of natural products has been greatly extended in recent years. However, a key question that remains to be answered is whether natural...