Manmeet Ahuja
Overview
Explore the profile of Manmeet Ahuja including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
544
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0
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Recent Articles
1.
Rabot C, Grau M, Entwistle R, Chiang Y, Zamora de Roberts Y, Ahuja M, et al.
J Nat Prod
. 2024 Sep;
87(10):2384-2392.
PMID: 39334518
Secondary metabolites are generally produced by enzymes encoded by genes within a biosynthetic gene cluster. Transcription factor genes are frequently located within these gene clusters. These transcription factors often drive...
2.
Grau M, Entwistle R, Chiang Y, Ahuja M, Oakley C, Akashi T, et al.
ACS Chem Biol
. 2018 Oct;
13(11):3193-3205.
PMID: 30339758
Fungi are a major source of valuable bioactive secondary metabolites (SMs). These compounds are synthesized by enzymes encoded by genes that are clustered in the genome. The vast majority of...
3.
Oakley C, Ahuja M, Sun W, Entwistle R, Akashi T, Yaegashi J, et al.
Mol Microbiol
. 2016 Oct;
103(2):347-365.
PMID: 27775185
Fungal secondary metabolites (SMs) are extremely important in medicine and agriculture, but regulation of their biosynthesis is incompletely understood. We have developed a genetic screen in Aspergillus nidulans for negative...
4.
Yeh H, Ahuja M, Chiang Y, Oakley C, Moore S, Yoon O, et al.
ACS Chem Biol
. 2016 Jun;
11(8):2275-84.
PMID: 27294372
Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce valuable compounds. Heterologous expression systems should allow these clusters to...
5.
Chiang Y, Ahuja M, Oakley C, Entwistle R, Asokan A, Zutz C, et al.
Angew Chem Int Ed Engl
. 2015 Nov;
55(5):1662-5.
PMID: 26563584
To reduce the secondary metabolite background in Aspergillus nidulans and minimize the rediscovery of compounds and pathway intermediates, we created a "genetic dereplication" strain in which we deleted eight of...
6.
Chiang Y, Oakley C, Ahuja M, Entwistle R, Schultz A, Chang S, et al.
J Am Chem Soc
. 2013 Apr;
135(20):7720-31.
PMID: 23621425
Fungal secondary metabolites (SMs) are an important source of medically valuable compounds. Genome projects have revealed that fungi have many SM biosynthetic gene clusters that are not normally expressed. To...
7.
Yeh H, Chiang Y, Entwistle R, Ahuja M, Lee K, Bruno K, et al.
Appl Microbiol Biotechnol
. 2012 May;
96(3):739-48.
PMID: 22627757
Genome sequencing of Aspergillus species including Aspergillus nidulans has revealed that there are far more secondary metabolite biosynthetic gene clusters than secondary metabolites isolated from these organisms. This implies that...
8.
Dave K, Ahuja M, Jayashri T, Sirola R, Punekar N
Enzyme Microb Technol
. 2012 May;
51(1):53-8.
PMID: 22579391
Selectable markers are valuable tools in transforming asexual fungi like Aspergillus niger. An arginase (agaA) expression vector and a suitable arginase-disrupted host would define a novel nutritional marker/selection for transformation....
9.
Ahuja M, Chiang Y, Chang S, Praseuth M, Entwistle R, Sanchez J, et al.
J Am Chem Soc
. 2012 Apr;
134(19):8212-21.
PMID: 22510154
Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been...
10.
Lo H, Entwistle R, Guo C, Ahuja M, Szewczyk E, Hung J, et al.
J Am Chem Soc
. 2012 Feb;
134(10):4709-20.
PMID: 22329759
Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of second-generation...