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Manabu Aoki

Explore the profile of Manabu Aoki including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 95
Citations 746
Followers 0
Related Specialties
Oncology
Radiology
Pharmacology
Top 10 Co-Authors
Hiroaki Mitsuya
Arun K Ghosh
Kenta Miki
Hiroyuki Takahashi
Debananda Das
Takahiro Kimura
Shin Egawa
Masayuki Amano
Hiroshi Sasaki
Fumihiko Urabe
Published In
Int J Clin Oncol
Antimicrob Agents Chemother
ChemMedChem
J Med Chem
J Virol
Affiliations
Soon will be listed here.
Recent Articles
1.
An orally available P1'-5-fluorinated M inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier
Higashi-Kuwata N, Bulut H, Hayashi H, Tsuji K, Ogata-Aoki H, Kiso M, et al.
PNAS Nexus . 2025 Jan; 4(1):pgae578. PMID: 39831159
We identified a 5-fluoro-benzothiazole-containing small molecule, TKB272, through fluorine-scanning of the benzothiazole moiety, which more potently inhibits the enzymatic activity of SARS-CoV-2's main protease (M) and more effectively blocks the...
2.
Ten-Year Outcomes of a Phase 3, Multicenter, Randomized Controlled Trial (SHIP0804) With 3-Month Neoadjuvant Androgen Deprivation Prior to I-Seed Transperineal Prostate Brachytherapy Followed by Nil Versus 9-Month Adjuvant Hormonal Therapy in...
Fukuokaya W, Miki K, Aoki M, Takahashi H, Saito S, Yorozu A, et al.
Int J Radiat Oncol Biol Phys . 2024 Nov; 121(4):875-884. PMID: 39551103
Purpose: To analyze the effects of adjuvant hormonal therapy (AHT) on time to event after neoadjuvant androgen deprivation therapy (ADT) and I-transperineal prostate brachytherapy (TPPB), compared with neoadjuvant ADT and...
3.
Optimizing prostate cancer detection in transition zone: an analysis of apparent diffusion coefficient values in prostate magnetic resonance imaging evaluation with Prostate Imaging Reporting and Data System (PI-RADS) assessment
Imai Y, Urabe F, Sadakane I, Oguchi T, Iwatani K, Murakami M, et al.
Transl Androl Urol . 2024 Oct; 13(9):2027-2035. PMID: 39434761
Background: Multiparametric magnetic resonance imaging (mpMRI) is increasingly used for the early detection of clinically significant prostate cancer (csPCa). However, the achievement of accurate detection rates, particularly for transition zone...
4.
The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy
Tsutsumi Y, Omura K, Kijima Y, Kobayashi M, Fukasawa N, Takeda T, et al.
Cancer Med . 2024 Mar; 13(5):e6943. PMID: 38497548
Background: We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross-departmental collaboration to enhance the effectiveness of cancer treatment. Methods: We retrospectively evaluated 22 patients...
5.
Clinical Significance of Intraductal Carcinoma of the Prostate After High-Dose Brachytherapy With External Beam Radiation Therapy: A Single Institution Series and an Updated Meta-Analysis
Miyajima K, Sato S, Uchida N, Suzuki H, Iwatani K, Imai Y, et al.
Clin Genitourin Cancer . 2023 Nov; 22(2):149-156.e1. PMID: 38007354
Background: We compared oncological outcomes between prostate cancer (PCa) patients with and without intraductal carcinoma of the prostate (IDC-P) after high-dose-rate brachytherapy (HDR-BT) with external beam radiation therapy (EBRT). Methods:...
6.
Correction to: Comparison of outcomes in high‑risk prostate cancer patients treated with low‑/high‑dose‑rate brachytherapy plus external beam radiotherapy
Imai Y, Urabe F, Iwatani K, Nakazono M, Tashiro K, Honda M, et al.
Int J Clin Oncol . 2023 Oct; 28(12):1697. PMID: 37812316
No abstract available.
7.
Predictive factors for disease progression after salvage radiation therapy in biochemical recurrent patients treated by radical prostatectomy
Aikawa K, Kimura S, Urabe F, Iwatani K, Tashiro K, Ochi A, et al.
Prostate Int . 2023 Sep; 11(3):145-149. PMID: 37745910
Objective: Salvage radiation therapy (SRT) is standard treatment for patients after radical prostatectomy (RP). However, the optimal timing of SRT remains to be elucidated. Material And Methods: We retrospectively reviewed...
8.
Patients with PSA below 0.2 ng/mL at 8 years post high-dose-rate brachytherapy have an extremely low risk of subsequent recurrence
Nakazono M, Urabe F, Iwatani K, Imai Y, Tashiro K, Honda M, et al.
Int J Urol . 2023 Aug; 30(12):1147-1154. PMID: 37650359
Objectives: We have analyzed the long-term follow-up data of patients with prostate cancer (PCa) who underwent high-dose-rate brachytherapy (HDR-BT) and external beam radiotherapy (EBRT) combined with long-term androgen deprivation therapy...
9.
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants
Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, et al.
Sci Adv . 2023 Jul; 9(28):eadg2955. PMID: 37436982
Nuclear localization signal (NLS) of HIV-1 integrase (IN) is implicated in nuclear import of HIV-1 preintegration complex (PIC). Here, we established a multiclass drug-resistant HIV-1 variant (HIV) by consecutively exposing...
10.
Clinical characteristics of secondary bladder cancer developing after low-/high-dose-rate brachytherapy to treat localized prostate cancer
Miyajima K, Suzuki H, Urabe F, Iwatani K, Imai Y, Yasue K, et al.
Int J Clin Oncol . 2023 Jul; 28(9):1200-1206. PMID: 37432614
Background: To explore correlations between the clinical attributes of secondary bladder cancer and brachytherapy, we retrospectively reviewed our institutional database on patients with localized prostate cancer who underwent low-dose-rate brachytherapy...