Man Shing Wong
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Explore the profile of Man Shing Wong including associated specialties, affiliations and a list of published articles.
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67
Citations
361
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Recent Articles
11.
Wang X, Chan H, Desbois N, Gros C, Bolze F, Li Y, et al.
ACS Appl Mater Interfaces
. 2021 Apr;
13(16):18525-18532.
PMID: 33852279
Despite the wide use of magnetic resonance imaging (MRI) as a clinical diagnostic tool, there are still no clinically approved MRI contrast agents that can be applied for cerebral Alzheimer's...
12.
Wang X, Wang C, Chan H, Ashok I, Krishnamoorthi S, Li M, et al.
Talanta
. 2020 Dec;
224:121830.
PMID: 33379048
To enable the early detection and intervention of Alzheimer's disease (AD), it is highly desirable to develop novel theranostic agents for simultaneous detection of toxic and pathogenic amyloid-β (Aβ) oligomers...
13.
Lin B, Fan L, Zhou Y, Ge J, Wang X, Dong C, et al.
J Mater Chem B
. 2020 Oct;
8(46):10586-10592.
PMID: 33125023
A mitochondrial pH sensing fluorescent probe namely 2-(2-(6-hydroxynaphthalen-2-yl)vinyl)-3-(6-(triphenyl-phosphonio)hexyl)benzothiazol-3-ium bromide (HTBT2) was designed and facilely synthesized via the Knoevenagel condensation reaction. HTBT2 displayed a linear fluorescence enhancement at 612 nm in...
14.
Ma Y, Ye Z, Zhang C, Wang X, Li H, Wong M, et al.
ACS Nano
. 2020 Aug;
14(9):11341-11351.
PMID: 32857496
Deposition and aggregation of β-amyloid (Aβ) peptides are demonstrated to be closely related to the pathogenesis of Alzheimer's disease (AD). Development of functional molecules capable of visualizing Aβ aggregates with...
15.
Fan L, Zan Q, Lin B, Wang X, Gong X, Zhao Z, et al.
Analyst
. 2020 Jul;
145(16):5657-5663.
PMID: 32638730
Hypoxia in solid tumors is directly linked to the elevated levels of endogenous nitroreductase (NTR). We present a novel fluorescent probe, namely NTNO, for nitroreductase-specific detection based on the NTR-catalyzed...
16.
Peng C, Wang X, Li Y, Li H, Wong M
J Mater Chem B
. 2020 Apr;
7(12):1986-1995.
PMID: 32254802
The self-aggregation of amyloid-β peptides into soluble oligomers and then into insoluble fibril-associated amyloid plaques is a key event in the progression of Alzheimer's disease (AD). The imaging of Aβ...
17.
Chen C, Xu D, Zhang Z, Jia S, Cao X, Chen Y, et al.
Exp Neurol
. 2020 Jan;
327:113210.
PMID: 31987831
Accumulation of β-amyloid (Aβ) peptide and hyperphosphorylated tau in the brain is one of the pathological characteristics of Alzheimer's disease (AD) and attractive therapeutic targets in its treatment. In the...
18.
Lin B, Fan L, Ying Z, Ge J, Wang X, Zhang T, et al.
Talanta
. 2019 Dec;
208:120279.
PMID: 31816747
Intracellular pH, especially cytoplasmic pH (~7.2) plays a crucial role in cell functions and metabolism. A ratiometric fluorescent probe namely, 6-(2-(benzothiazol-2-yl)vinyl)naphthalen-2-ol (BTNO) was facilely synthesized by the condensation of 6-hydroxy-2-naphthaldehyde...
19.
Wang X, Ho S, Poon C, Yan T, Li H, Wong M
Curr Alzheimer Res
. 2019 Aug;
16(9):836-842.
PMID: 31453789
Background: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capability of scavenging free radicals, suggesting its potential for the prevention of neurodegeneration....
20.
Chan H, Xu D, Ho S, He D, Wong M, Li H
Theranostics
. 2019 Jun;
9(10):2939-2949.
PMID: 31244934
Alzheimer's disease (AD), a chronic neurodegenerative disease associated with the loss of neurons in the brain, is the most pervasive type of dementia; 47 million people are affected, and the...