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Man P Ngan

Explore the profile of Man P Ngan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 122
Followers 0
Related Specialties
Pharmacology
Physiology
Psychiatry
Top 10 Co-Authors
John A Rudd
Zengbing Lu
Longlong Tu
Emanuela Lovati
Claudio Giuliano
Claudio Pietra
Kelvin K W Kan
Man K Wai
Paul L R Andrews
Sze Wa Chan
Published In
Front Pharmacol
Eur J Pharmacol
Front Physiol
Physiol Behav
J Pharmacol Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism
Lu Z, Ngan M, Liu J, Yang L, Tu L, Chan S, et al.
Physiol Behav . 2024 Jul; 284:114644. PMID: 39043357
This study investigated whether ghrelin mimetics, namely anamorelin and ipamorelin, can alleviate weight loss and inhibition of feeding observed during acute and delayed phases of cisplatin-induced emesis in ferrets. The...
2.
Insights Into Acute and Delayed Cisplatin-Induced Emesis From a Microelectrode Array, Radiotelemetry and Whole-Body Plethysmography Study of (House Musk Shrew)
Tu L, Liu J, Lu Z, Cui D, Ngan M, Du P, et al.
Front Pharmacol . 2021 Dec; 12:746053. PMID: 34925008
Cancer patients receiving cisplatin therapy often experience side-effects such as nausea and emesis, but current anti-emetic regimens are suboptimal. Thus, to enable the development of efficacious anti-emetic treatments, the mechanisms...
3.
Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches
Lu Z, Zhou Y, Tu L, Chan S, Ngan M, Cui D, et al.
Front Physiol . 2021 Jan; 11:583082. PMID: 33488391
Nausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical techniques can determine the relative degrees of brady-, normo-, and...
4.
The brain-penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion-induced emesis in Suncus murinus (house musk shrew)
Tu L, Lu Z, Ngan M, Lam F, Giuliano C, Lovati E, et al.
Br J Pharmacol . 2019 Nov; 177(7):1635-1650. PMID: 31722444
Background And Purpose: HM01, a novel, orally bioavailable, brain-penetrating agonist of ghrelin receptors, ameliorates emesis in Suncus murinus. This study compared HM01's activity against motion sickness with that of the...
5.
Corrigendum: Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT Antagonist, Palonosetron and With the NK Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in (House Musk...
Rudd J, Chan S, Ngan M, Tu L, Lu Z, Giuliano C, et al.
Front Pharmacol . 2018 Oct; 9:1102. PMID: 30310382
[This corrects the article DOI: 10.3389/fphar.2018.00869.].
6.
Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT Antagonist, Palonosetron and With the NK Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in (House Musk Shrew)
Rudd J, Chan S, Ngan M, Tu L, Lu Z, Giuliano C, et al.
Front Pharmacol . 2018 Aug; 9:869. PMID: 30127745
Highlights: - The novel orally bioavailable brain-penetrating GHS-R1A agonist, HM01 (1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-Methyl-3,3-dimethyl-4-piperidyl]urea), antagonizes motion- and cisplatin-induced emesis.- HM01 did not reduce emesis induced by nicotine or by intragastric copper sulfate.- HM01...
7.
Establishment of a radiotelemetric recording technique in mice to investigate gastric slow waves: Modulatory role of putative neurotransmitter systems
Wang H, Lu Z, Liu Y, Sun Y, Tu L, Ngan M, et al.
Exp Physiol . 2018 Apr; 103(6):827-837. PMID: 29667248
New Findings: What is the central question of this study? Gastric slow waves originating from the interstitial cells of Cajal-smooth muscle syncytium are usually studied in culture or in tissue...
8.
Gastric myoelectric activity during cisplatin-induced acute and delayed emesis reveals a temporal impairment of slow waves in ferrets: effects not reversed by the GLP-1 receptor antagonist, exendin (9-39)
Lu Z, Ngan M, Lin G, Yew D, Fan X, Andrews P, et al.
Oncotarget . 2017 Dec; 8(58):98691-98707. PMID: 29228720
Preclinical studies show that the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin (9-39), can reduce acute emesis induced by cisplatin. In the present study, we investigate the effect of exendin (9-39)...
9.
Brain Activation by H Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in (House Musk Shrew)
Tu L, Lu Z, Dieser K, Schmitt C, Chan S, Ngan M, et al.
Front Physiol . 2017 Jun; 8:412. PMID: 28659825
Motion sickness occurs under a variety of circumstances and is common in the general population. It is usually associated with changes in gastric motility, and hypothermia, which are argued to...
10.
Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew)
Rudd J, Ngan M, Lu Z, Higgins G, Giuliano C, Lovati E, et al.
Front Pharmacol . 2016 Sep; 7:263. PMID: 27630563
Background And Aims: Chemotherapy-induced acute and delayed emesis involves the activation of multiple pathways, with 5-hydroxytryptamine (5-HT; serotonin) playing a major role in the initial response. Substance P tachykinin NK1...